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Volume 31, Number 2—February 2025
Research Letter

Sin Nombre Virus as Unlikely Reverse Zoonotic Threat

Jérémie Prévost, Nikesh Tailor, Anders Leung, Bryce Warner1, and David SafronetzComments to Author 
Author affiliation: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (J. Prévost, N. Tailor, A. Leung, B. Warner, D. Safronetz); University of Manitoba, Winnipeg (D. Safronetz)

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Figure

Experimental infection of North American deer mice (Peromyscus maniculatus) with Sin Nombre virus (SNV) to determine whether direct inoculation with clinical material would enable isolation of virus without prior Vero propagation. Infection of humans or nonhuman primates with deer mouse–derived SNV causes HCPS. This study shows that SNV retrieved from HCPS cases or infected nonhuman primates does not generate a productive infection in deer mice. SNV can also infect the Vero cell line upon passaging and adaption, but it reduces its infectivity in deer mice compared with deer mouse–only passaged SNV. The figure was prepared using images from BioRender.com (https://www.biorender.com). HCPS, hantavirus cardiopulmonary syndrome.

Figure. Experimental infection of North American deer mice (Peromyscus maniculatus) with Sin Nombre virus (SNV) to determine whether direct inoculation with clinical material would enable isolation of virus without prior Vero propagation. Infection of humans or nonhuman primates with deer mouse–derived SNV causes HCPS. This study shows that SNV retrieved from HCPS cases or infected nonhuman primates does not generate a productive infection in deer mice. SNV can also infect the Vero cell line upon passaging and adaption, but it reduces its infectivity in deer mice compared with deer mouse–only passaged SNV. The figure was prepared using images from BioRender.com (https://www.biorender.com). HCPS, hantavirus cardiopulmonary syndrome.

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1Current affiliation: Vaccine and Infectious Disease Organization, Saskatoon, Saskatchewan, Canada.

Page created: December 06, 2024
Page updated: January 31, 2025
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