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Volume 31, Number 3—March 2025
Synopsis

Corynebacterium diphtheriae Infections, South Africa, 2015–2023

Mignon du PlessisComments to Author , Rito Mikhari, Linda de Gouveia, Noluthando Duma, Tamsin Lovelock, Charlene Lawrence, Prasha Mahabeer, Yesholata Mahabeer, Nevashan Govender, Susan Nzenze, Jonathan Featherston, Mishalan Moodley, Jocelyn Moyes, Sibongile Walaza, Cheryl Cohen, and Anne von Gottberg
Author affiliation: National Health Laboratory Service, Johannesburg, South Africa (M. du Plessis, R. Mikhari, L. de Gouveia, N. Duma, N. Govender, S. Nzenze, J. Featherston, M. Moodley, J. Moyes, S. Walaza, C. Cohen, A. von Gottberg); University of the Witwatersrand, Johannesburg (M. du Plessis, R. Mikhari, S. Walaza, C. Cohen, A. von Gottberg); Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa (T. Lovelock); Western Cape Department of Health, Cape Town (C. Lawrence); National Health Laboratory Service, Durban, South Africa (P. Mahabeer, Y. Mahabeer); University of Kwazulu-Natal, Durban (P. Mahabeer, Y. Mahabeer); University of Cape Town, Cape Town (A. von Gottberg)

Main Article

Figure 2

Phylogenetic analysis of Corynebacterium diphtheriae isolates, South Africa, 2015–2023. Total number of isolates was 84 from 83 patients. Isolate identification numbers are listed on the right side of the colored bars. Colored columns indicate presence/absence of the tox gene, sequence type, sublineage, location of isolate, year isolate was collected, and clinical infection type. Neighbor-joining tree was generated by using the core genome multilocus sequence typing scheme in the Insitut Pasteur Bacterial Isolate Genome Sequence C. diphtheriae database (https://bigsdb.pasteur.fr/diphtheria). Tree was visualized by using iTOL (https://itol.embl.de) and rooted by using a tox gene–negative C. diphtheriae genome (no. 1597 at top) isolated from South Africa circa 1980 (clinical isolate with no available clinical or demographic data). Scale bar indicates nucleotide substitutions per site. ST, sequence type.

Figure 2. Phylogenetic analysis of Corynebacterium diphtheriae isolates, South Africa, 2015–2023. Total number of isolates was 84 from 83 patients. Isolate identification numbers are listed on the right side of the colored bars. Colored columns indicate presence/absence of the tox gene, sequence type, sublineage, location of isolate, year isolate was collected, and clinical infection type. Neighbor-joining tree was generated by using the core genome multilocus sequence typing scheme in the Insitut Pasteur Bacterial Isolate Genome Sequence C. diphtheriae database (https://bigsdb.pasteur.fr/diphtheria). Tree was visualized by using iTOL (https://itol.embl.de) and rooted by using a tox gene–negative C. diphtheriae genome (no. 1597 at top) isolated from South Africa circa 1980 (clinical isolate with no available clinical or demographic data). Scale bar indicates nucleotide substitutions per site. ST, sequence type.

Main Article

Page created: January 15, 2025
Page updated: March 07, 2025
Page reviewed: March 07, 2025
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