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Volume 31, Number 4—April 2025
Research

Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States

Jianping Jiang, Tengfei Long, Adeline R. Porter, Arianne Lovey, Annie Lee, Jesse Thomas Jacob, Cesar A. Arias, Robert Bonomo, Robert Kalayjian, Yanan Zhao, Frank R. DeLeo, David van Duin, Barry N. KreiswirthComments to Author , and Liang ChenComments to Author 
Author affiliation: Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA (J. Jiang, T. Long, A. Lovey, A. Lee, Y. Zhao, B.N. Kreiswirth, L. Chen); National Institute of Allergy and Infectious Disease Rocky Mountain Laboratories, Hamilton, Montana, USA (A.R. Porter, F.R. DeLeo); Emory University, Atlanta, Georgia, USA (J.T. Jacob); Houston Methodist Hospital and Houston Methodist Research Institute, Houston, Texas, USA (C.A. Arias); Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA (R.A. Bonomo); Case Western Reserve University School of Medicine, Cleveland (R.A. Bonomo); MetroHealth Medical Center, Cleveland (R. Kalayjian); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (D. van Duin)

Main Article

Figure 5

Virulence comparison of 3 selected isolates in study of carbapenem-resistant, virulence plasmid–harboring Klebsiella pneumoniae isolates, United States. Virulence phenotypes were determined in a murine model of K. pneumoniae pneumonia. A) Changes in mouse weight relative to the baseline at 0 h during the course of infection (n = 5). Results represent the mean (dots) + standard deviation (t bars) of the indicated number of samples. Asterisks (*) indicate p<0.05 vs. 24 h; hash marks (#) indicate p<0.05 vs. ATCC43816. B–D) Bacteria recovered from mouse lungs at 2 h (B, n = 3) and 48 h (C, n = 5) postinfection and from spleens at 48 h postinfection (D, n = 5). Individual CFU values (dots) and mean values (horizontal lines) are shown. We used t-tests for all the comparisons. Dashed lines indicate limits of detection. KL, capsular locus; ST, sequence type.

Figure 5. Virulence comparison of 3 selected isolates in study of carbapenem-resistant, virulence plasmid–harboring Klebsiella pneumoniae isolates, United States. Virulence phenotypes were determined in a murine model of K. pneumoniae pneumonia. A) Changes in mouse weight relative to the baseline at 0 h during the course of infection (n = 5). Results represent the mean (dots) + standard deviation (t bars) of the indicated number of samples. Asterisks (*) indicate p<0.05 vs. 24 h; hash marks (#) indicate p<0.05 vs. ATCC43816. B–D) Bacteria recovered from mouse lungs at 2 h (B, n = 3) and 48 h (C, n = 5) postinfection and from spleens at 48 h postinfection (D, n = 5). Individual CFU values (dots) and mean values (horizontal lines) are shown. We used t-tests for all the comparisons. Dashed lines indicate limits of detection. KL, capsular locus; ST, sequence type.

Main Article

Page created: February 18, 2025
Page updated: March 11, 2025
Page reviewed: March 11, 2025
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