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Volume 31, Number 4—April 2025
Research

Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States

Jianping Jiang, Tengfei Long, Adeline R. Porter, Arianne Lovey, Annie Lee, Jesse Thomas Jacob, Cesar A. Arias, Robert Bonomo, Robert Kalayjian, Yanan Zhao, Frank R. DeLeo, David van Duin, Barry N. KreiswirthComments to Author , and Liang ChenComments to Author 
Author affiliation: Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA (J. Jiang, T. Long, A. Lovey, A. Lee, Y. Zhao, B.N. Kreiswirth, L. Chen); National Institute of Allergy and Infectious Diseases Rocky Mountain Laboratories, Hamilton, Montana, USA (A.R. Porter, F.R. DeLeo); Emory University, Atlanta, Georgia, USA (J.T. Jacob); Houston Methodist Hospital and Houston Methodist Research Institute, Houston, Texas, USA (C.A. Arias); Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA (R.A. Bonomo); Case Western Reserve University School of Medicine, Cleveland (R.A. Bonomo); MetroHealth Medical Center, Cleveland (R. Kalayjian); University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (D. van Duin)

Main Article

Figure 3

Capsule heterogeneity in 6 clinical isolates and reference isolates in study of carbapenem-resistant, virulence plasmid–harboring Klebsiella pneumoniae isolates, United States. A) Hypermucoid index scores; B) capsule production measured by uronic acid content of isolates displaying different mucoidity. The hypermucoid index and uronic acid production of the 6 isolates were compared to those of ATCC 43816 and NJST 258–2 using t-tests. Asterisk (*) indicates p<0.05 vs. ATCC43816; hash mark (#) indicates p<0.05 vs. NJST258_2. Results represent the mean (bars) + SDs (error bars) of 3 samples for each isolate. KL, capsular locus; OD600, optical density at 600 nm; ST, sequence type.

Figure 3. Capsule heterogeneity in 6 clinical isolates and reference isolates in study of carbapenem-resistant, virulence plasmid–harboring Klebsiella pneumoniae isolates, United States. A) Hypermucoid index scores; B) capsule production measured by uronic acid content of isolates displaying different mucoidity. The hypermucoid index and uronic acid production of the 6 isolates were compared to those of ATCC 43816 and NJST 258–2 using t-tests. Asterisk (*) indicates p<0.05 vs. ATCC43816; hash mark (#) indicates p<0.05 vs. NJST258_2. Results represent the mean (bars) + SDs (error bars) of 3 samples for each isolate. KL, capsular locus; OD600, optical density at 600 nm; ST, sequence type.

Main Article

Page created: February 18, 2025
Page updated: March 24, 2025
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