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Volume 31, Number 5—May 2025
Dispatch

Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024

Emi TakashitaComments to Author , Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Tatsuya Ikeda, Kenichi Komabayashi, Mika Sasaki, Yohei Matoba, Tomoko Takahashi, Naomi Ogawa, Katsumi Mizuta, Sueshi Ito, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Shinji Watanabe, and Hideki Hasegawa
Author affiliation: Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (E. Takashita, H. Morita, S. Nagata, S. Fujisaki, H. Miura, N. Kishida, K. Nakamura, M. Shirakura, S. Watanabe, H. Hasegawa); Yamagata Prefectural Institute of Public Health, Yamagata, Japan (T. Ikeda, K. Komabayashi, M. Sasaki, Y. Matoba, T. Takahashi, N. Ogawa, K. Mizuta); Ito Clinic, Yamagata (S. Ito)

Main Article

Table 2

Amino acid differences in influenza A(H1N1)pdm09 viruses with reduced susceptibility to baloxavir, Japan, 2024*

Influenza virus PA
 PB1
 PB2
 HA
 NA
 NS1
38 258 531 617 622 661 152 308 649 6 274 51 383 178
A/Yamagata/103/2024 N E K D G T S I I V V E T I
A/Yamagata/333/2023 T E R N G A A V V I M K T V
A/Yamagata/336/2023 I K R D R A A V V V M K I V

*HA, hemagglutinin; NA, neuraminidase; NS1, nonstructural protein 1; PA, polymerase acidic protein; PB1, polymerase basic protein 1; PB2, polymerase basic protein 2.

Main Article

Page created: March 19, 2025
Page updated: April 25, 2025
Page reviewed: April 25, 2025
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