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Volume 31, Number 5—May 2025

Dispatch

Rapid Transmission and Divergence of Vancomycin-Resistant Enterococcus faecium Sequence Type 80, China

Liqiang Li1, Xingwei Wang1, Yanyu Xiao, Bing Fan, Jiehong Wei, Jie Zhou, Zetian Lai, Yanpeng Zhang, Hongmei Mo, Li Zhang, Dixian Luo, Dayong Gu, Shucai Yang, Yidi Wang, Jiuxin QuComments to Author , and Shenzhen Pathogen Infection Research Alliance (SPIRA)
Author affiliation: Shenzhen Third People’s Hospital Department of Clinical Laboratory; National Clinical Research Center for Infectious Diseases, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China (L. Li, X. Wang, Y. Xiao, Y. Wang, J. Qu); Shenzhen Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen (B. Fan, Y. Zhang, D. Gu); Medical Laboratory of the Third Affiliated Hospital of Shenzhen University, Shenzhen (J. Wei, H. Mo); Pingshan Hospital, Southern Medical University, Pingshan District People’s Hospital of Shenzhen, Shenzhen (J. Zhou, L. Zhang, S. Yang); Shenzhen Nanshan People's Hospital, Shenzhen (Z. Lai, D. Luo); Shenzhen University Medical School, Shenzhen (Z. Lai, D. Luo)

Main Article

Table

Distribution of insertion sequences associated with 3 recombination regions during rapid transmission and divergence of vancomycin-resistant Enterococcus faecium sequence type 80, China*

Region SC11 IS+ sample IS91 ISL3 IS1182 IS200/IS605 IS256 IS3 IS66 IS982 IS30
Recomb1
 SC11-pop I 0 0 0 0 0 0 0 0 0 0
SC11-pop II 31 24† 23 1 3 11 0 0 0 0
Proportion of SC11-pop II‡
 31/35
 24/35‡
 23/35
 1/35
 3/35
 11/35
 0
 0
 0
 0
Recomb2
 SC11-pop I 80 0 4 0 0 1 81 3 2 1
SC11-pop II 8 0 0 0 0 0 8 0 0 0
Proportion of SC11-pop I 80/200 0 2/200 0 0 1/200 78/200 3/200 2/200 1/200
Proportion of SC11-pop II
 8/35
 0
 0/35
 0
 0
 0/35
 8/35
 0/35
 0/35
 0/35
Recomb3 SC11-pop I 0 0 0 0 0 0 0 0 0 0
SC11-pop II 7 0 0 0 0 0 7 0 0 0
Proportion of SC11-pop II 7/35 0 0 0 0 0 7/35 0 0 0

*SC11-pop I, n = 200 strains; SC11-pop II, n = 35 strains. For identifying the associated IS, in certain Recomb modulars, the upstream (5 kb) and downstream (5 kb) of each Recomb component gene were searched using ISEscan v1.7.2.3 (14). IS, insertion sequence; pop, population; SC11, sequence cluster 11; +, positive. †Total IS number can be identified. ‡The frequency of isolates carrying the corresponding IS.

Main Article

1These authors contributed equally to this article.

Page created: March 24, 2025
Page updated: April 25, 2025
Page reviewed: April 25, 2025
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