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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 8—August 2025

Perspective

A Roadmap of Primary Pandemic Prevention Through Spillover Investigation

Emily S. GurleyComments to Author  and Raina K. Plowright
Author affiliation: Johns Hopkins University, Baltimore, Maryland, USA (E.S. Gurley); Cornell University, Ithaca, New York, USA (R.K. Plowright).

Main Article

Figure 2

A roadmap of primary pandemic prevention through spillover investigation from discovery to the prevention of zoonotic spillover. The pathway from discovery of a zoonotic pathogen in reservoir hosts to the prevention of future spillovers often begins with the detection of spillovers in persons or domestic animals. If those detections prompt One Health investigations, followed by in-depth studies to identify the root causes of spillover, the resulting knowledge can inform the design, testing and implementation of interventions to address both proximal and distal drivers of spillover risk.

Figure 2. A roadmap of primary pandemic prevention through spillover investigation from discovery to the prevention of zoonotic spillover. The pathway from discovery of a zoonotic pathogen in reservoir hosts to the prevention of future spillovers often begins with the detection of spillovers in persons or domestic animals. If those detections prompt One Health investigations, followed by in-depth studies to identify the root causes of spillover, the resulting knowledge can inform the design, testing and implementation of interventions to address both proximal and distal drivers of spillover risk.

Main Article

Page created: July 02, 2025
Page updated: July 11, 2025
Page reviewed: July 11, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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