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Volume 31, Number 8—August 2025

Research

Estimated COVID-19 Periodicity and Correlation with SARS-CoV-2 Spike Protein S1 Antigenic Diversity, United States

Erica Billig RoseComments to Author , Clinton R. Paden, Peter W. Cook, Kevin C. Ma, Amber Winn, Juan Castro, Lakshmi Panagiotakopoulos, and Benjamin J. Silk
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Figure 3

Weekly numbers of sequenced SARS-CoV-2 isolates, proportions with unique S1 spike sequences, and national percentages of positive SARS-CoV-2 tests and percentage changes in SDI, United States, October 2020–September 2024. A) Numbers of sequenced isolates (gray bars) and proportions of isolates with each unique S1 sequence (colored lines). Unique S1 sequences with a maximum proportion of <0.02 during the study period are included in the total number of isolates but not shown as proportion lines to improve visibility of patterns. B) National smoothed (3-week) percentages of positive SARS-CoV-2 tests reported to the NREVSS and percentage changes in SDI of S1 spike proteins. NREVSS, National Respiratory and Enteric Surveillance System; SDI, Simpson diversity index.

Figure 3. Weekly numbers of sequenced SARS-CoV-2 isolates, proportions with unique S1 spike sequences, and national percentages of positive SARS-CoV-2 tests and percentage changes in SDI, United States, October 2020–September 2024. A) Numbers of sequenced isolates (gray bars) and proportions of isolates with each unique S1 sequence (colored lines). Unique S1 sequences with a maximum proportion of <0.02 during the study period are included in the total number of isolates but not shown as proportion lines to improve visibility of patterns. B) National smoothed (3-week) percentages of positive SARS-CoV-2 tests reported to the NREVSS and percentage changes in SDI of S1 spike proteins. NREVSS, National Respiratory and Enteric Surveillance System; SDI, Simpson diversity index.

Main Article

Page created: June 18, 2025
Page updated: July 10, 2025
Page reviewed: July 10, 2025
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