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Volume 31, Number 9—September 2025

Dispatch

CYP2D6 Genotype and Primaquine Treatment in Patients with Malaria, Venezuela

César Pacheco, Adán Hernández-Acosta, Narviz Pulido, Yvanna Ceballos, Daniel Saavedra, Cruz Gómez, Nancy Moreno1, and Flor Herrera1Comments to Author 
Author affiliation: Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico (C. Pacheco); Instituto de Investigación en Ciencias de la Salud de la Secretaría de Marina, Polígono Naval de San Pablo Tepetlapa, Mexico City (A. Hernández-Acosta); Universidad de Carabobo, Sede Aragua, Facultad de Ciencias de la Salud, Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso,” Estado Carabobo, Venezuela (N. Pulido, Y. Ceballos, D. Saavedra, N. Moreno, F. Herrera); FUNDASALUD Sucre, Dirección Estadal de Salud Ambiental, Sucre, Venezuela (C. Gómez)

Main Article

Table

Genotypes CYP2D6*4 and CYP2D6*6 and predicted phenotypes malaria and non malaria in patients with suspected malaria, Venezuela

Genotype Activity score Predicted phenotype Nonmalaria patients, no. (%), n = 52 Malaria patients, no. (%), n = 44
1*1 2 Normal metabolizer 39 (75) 33 (75)
1*4 1 Intermediate metabolizer 9 (17.31) 8 (18.19)
1*6 1 Intermediate metabolizer 2 (3.85) 1 (2.27)
4*4 0 Poor metabolizer 1 (1.92) 1 (2.27)
6*6 0 Poor metabolizer 0 1 (2.27)
6*4 0 Poor metabolizer 1 (1.92) 0

Main Article

1These authors were co–principal investigators.

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Page updated: August 26, 2025
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