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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 32, Number 1—January 2026

Synopsis

Pulmonary Histoplasmosis, Taiwan, 1997–2024

Ting-Wei Kao, Shang-Chen Yang, Hsiang-Wei Hu, Yu-Tsung Huang, Chin-Chung ShuComments to Author , and Wang-Huei Sheng
Author affiliation: National Taiwan University Hospital, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (T.-W. Kao, S.-C. Yang, C-.C. Shu, W.-H. Sheng); National Taiwan University Hospital, Department of Pathology, Taipei (H.-W. Hu); National Taiwan University Hospital, Department of Laboratory Medicine, National Taiwan University College of Medicine, Taipei (Y.-T. Huang); Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei (C.-C. Shu); National Taiwan University Hospital Hsinchu Branch, Department of Internal Medicine, Hsinchu, Taiwan (W.-H. Sheng)

Main Article

Table 1

Characteristics of case-patients in study of pulmonary histoplasmosis in Taiwan, 1997–2024*

Case no. Age, y/
sex Date Travel history Occupation Pet Residence region Involved site (details) Immunocompromised factor Antifungal agent
With lung involvement
1 21/F 2001 Apr USA (Illinois)† Teacher None North Lung (nodule) Immunocompetent None
2‡ 86/M 2003 Feb Indonesia,† Thailand,† Saudi Arabia, China (Shandong) Excavator driver None North Lung (nodule) Addison’s disease Amphotericin B
3 71/M 2014 Aug India,† Guatemala,† USA (California) Electronics None North Lung (nodule) Immunocompetent None
4 20/F 2016 Jul None Student None North Lung (nodule) Immunocompetent Voriconazole
5 74/F 2016 Jul None Housewife None North Lung (nodule) Immunocompetent Posaconazole
6 36/M 2019 Aug None Office worker None North Lung (nodule) Immunocompetent Voriconazole
7 32/M 2019 Dec None Unknown None Middle Lung (nodule) Immunocompetent Posaconazole
8 66/M 2020 May None Unknown None North Disseminated (involving skin, lymph node, and GI tract) Kidney transplant Voriconazole
9 54/M Mar 2021 None Electronic engineering None North Lung (nodule) Immunocompetent Itraconazole
10 53/M Oct 2021 None Cement worker None Middle Lung (nodule) Immunocompetent None
11 83/F Dec 2021 None None None North Lung (consolidation) Rheumatoid arthritis Voriconazole
12 63/F Sep 2023 None Housewife None Middle Lung (nodule) Immunocompetent Fluconazole
13 60/F 2023 Sep None Indoor decoration Duck North Lung (ill-defined opacity), bone marrow Myelodysplasic syndrome Ambisome
14§
 74/M
 2024 Sep
 None
 Cement worker
 None
 Middle
 Lung (nodule)
 Immunocompetent
 Voriconazole
Without lung involvement
15 27/M 1997 Jun Malaysia,† Thailand,† Singapore† Unknown None North Disseminated (involving lung, bone marrow, GI tract, and lymph node) HIV Amphotericin B
16 78/M 2003 Oct None Farmer None East Mediastinal lymph node None Amphotericin B

*GI, gastrointestinal. †These areas likely to be hyperendemic, cases likely to occur regularly, and locally acquired cases to be reported. ‡Patient died of respiratory failure. §Patient survived with Evans syndrome.

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Page created: December 06, 2025
Page updated: January 08, 2026
Page reviewed: January 08, 2026
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