Table 1

Volume 32, Number 1—January 2026

Genomic Insights into Marburg Virus Strains from 2023 and 2025 Outbreaks in Kagera, Tanzania

Lawrence A. Mapunda¹, Medard Beyanga¹, Nyambura Moremi

, Jean N. Hakizimana, Doreen Kamori, Alfred Chacha, Edna Mgimba, Dennis Mrosso, Ambele E. Mwafulango, Jackson Mushumbusi, Ferdinand Ndunguru, Seif Abdul, Emmanuel Mkumbo, Maria E. Kelly, Céline Barnadas, Vida Mmbaga, Rogath Kishimba, Samwel Laizer, Ntuli Kapologwe, Michael Kiremeji, Erasto Sylvanus, Angela Samwel, Saumu Nungu, Emmanuel Achol, Julien Nguinkal, Hakimu Idris Lagu, Muna Affara, Florian Gehre, Calvin Sindato, Chacha Mangu, Elias Nyanda Ntinginya, Saida Murugwa, Pawan Angra, Shannon Whitmer, George Mgomella, Mahesh Swaminathan, Wangeci Gatei, Dorcas Wanjohi, Sofonias Tessema, Yenew Kebede, Said Aboud, Charles Sagoe-Moses, Alex Magesa, Gerald Misinzo, Tumaini Nagu, and Grace Magembe

Author affiliation: National Public Health Laboratory, Dar es Salaam, Tanzania (L.A. Mapunda, N. Moremi, A. Chacha, E. Mgimba, D. Mrosso, A.E. Mwafulango, J. Mushumbusi, F. Ndunguru, S. Abdul); Ministry of Health, Dodoma, Tanzania (M. Beyanga, E. Mkumbo, V. Mmbaga, R. Kishimba, S. Laizer, N. Kapologwe, M. Kiremeji, E. Sylvanus, A. Samwel, S. Nungu, A. Magesa, T. Nagu, G. Magembe); Sokoine University of Agriculture, Morogoro, Tanzania (J.N. Hakizimana, G. Misinzo); Muhimbili University of Health and Allied Sciences, Dar es Salaam (D. Kamori); World Health Organization, Dar es Salaam (M.E. Kelly, C. Sagoe-Moses); World Health Organization, Geneva, Switzerland (C. Barnadas); East African Community, Arusha, Tanzania (E. Achol, J. Nguinkal, H.I. Lagu, M. Affara, F. Gehre); Bernhard Notch Institute for Tropical Medicine, Hamburg, Germany (M. Affara, F. Gehre); National Institute for Medical Research, Dodoma (C. Sindato, C. Mangu, E.N. Ntinginya, S. Aboud); US Centers for Disease Control and Prevention, Dar es Salaam (S. Murugwa, P. Angra, S. Whitmer, G. Mgomella, M. Swaminathan, W. Gatei); Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia (D. Wanjohi, S. Tessema, Y. Kebede)

Main Article

Patient metadata and sequence metrics from study of 2023 and 2025 MARV outbreaks in Kagera region, northwestern Tanzania*

Characteristic	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Sequence ID	MARV/H.Sapiens/TZ/Kagera/S6/2023	MARV/H.Sapiens/TZ/Kagera/S7/2023	MARV/H.Sapiens/TZ/Kagera/S8/2023	MARV/H.Sapiens/TZ/Kagera/001/2025	MARV/H.Sapiens/TZ/Kagera/002/2025
Patient age, y/sex	26/M	27/M	36/M	28/M	30/M
Location	Bulinda	Butahyaibega	Butahyaibega	Katerela	Ruziba
Ct value	24.41	18.73	19.74	25.28	16.34
Total sequencing reads	10,899,272	5,213,734	7,809,532	23,905,276	9,523,562
Mean base Phred quality score	35.4	35.2	35.4	37.4	37.3
No. MARV-specific sequencing reads	17,339	256,285	1,132,206	7,049,308	4,245,624
Mapped reads, %	0.16	4.91	14.46	29.49	44
Assembled MARV genome size, bp	18,943	19,054	19,048	19,070	19,030
GC content, %	38.28	38.18	38.07	38.10	38.01
Mean genome coverage depth	128.166	1,875.16	8,344.77	46,400	29,600
Genome coverage, %	99.12	99.70	99.67	99.89	99.57
GenBank accession no.	PV700539	PV700540	PV700541	PV700537	PV700538

*Ct, cycle threshold; GC, percentage of guanine (G) and cytosine (C) nucleotides; ID, identification; MARV, Marburg virus.

Main Article

¹These first authors contributed equally to this article.

Page created: December 18, 2025

Page updated: January 29, 2026

Page reviewed: January 29, 2026

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