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Volume 32, Number 1—January 2026

Research

Genomic Insights into Marburg Virus Strains from 2023 and 2025 Outbreaks in Kagera, Tanzania

Lawrence A. Mapunda1, Medard Beyanga1, Nyambura MoremiComments to Author , Jean N. Hakizimana, Doreen Kamori, Alfred Chacha, Edna Mgimba, Dennis Mrosso, Ambele E. Mwafulango, Jackson Mushumbusi, Ferdinand Ndunguru, Seif Abdul, Emmanuel Mkumbo, Maria E. Kelly, Céline Barnadas, Vida Mmbaga, Rogath Kishimba, Samwel Laizer, Ntuli Kapologwe, Michael Kiremeji, Erasto Sylvanus, Angela Samwel, Saumu Nungu, Emmanuel Achol, Julien Nguinkal, Hakimu Idris Lagu, Muna Affara, Florian Gehre, Calvin Sindato, Chacha Mangu, Elias Nyanda Ntinginya, Saida Murugwa, Pawan Angra, Shannon Whitmer, George Mgomella, Mahesh Swaminathan, Wangeci Gatei, Dorcas Wanjohi, Sofonias Tessema, Yenew Kebede, Said Aboud, Charles Sagoe-Moses, Alex Magesa, Gerald Misinzo, Tumaini Nagu, and Grace Magembe
Author affiliation: National Public Health Laboratory, Dar es Salaam, Tanzania (L.A. Mapunda, N. Moremi, A. Chacha, E. Mgimba, D. Mrosso, A.E. Mwafulango, J. Mushumbusi, F. Ndunguru, S. Abdul); Ministry of Health, Dodoma, Tanzania (M. Beyanga, E. Mkumbo, V. Mmbaga, R. Kishimba, S. Laizer, N. Kapologwe, M. Kiremeji, E. Sylvanus, A. Samwel, S. Nungu, A. Magesa, T. Nagu, G. Magembe); Sokoine University of Agriculture, Morogoro, Tanzania (J.N. Hakizimana, G. Misinzo); Muhimbili University of Health and Allied Sciences, Dar es Salaam (D. Kamori); World Health Organization, Dar es Salaam (M.E. Kelly, C. Sagoe-Moses); World Health Organization, Geneva, Switzerland (C. Barnadas); East African Community, Arusha, Tanzania (E. Achol, J. Nguinkal, H.I. Lagu, M. Affara, F. Gehre); Bernhard Notch Institute for Tropical Medicine, Hamburg, Germany (M. Affara, F. Gehre); National Institute for Medical Research, Dodoma (C. Sindato, C. Mangu, E.N. Ntinginya, S. Aboud); US Centers for Disease Control and Prevention, Dar es Salaam (S. Murugwa, P. Angra, S. Whitmer, G. Mgomella, M. Swaminathan, W. Gatei); Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia (D. Wanjohi, S. Tessema, Y. Kebede)

Main Article

Table 2

Comparison of amino acid mutations in Marburg virus strains in study of Marburg virus disease outbreaks in 2023 and 2025, Tanzania*

Gene 2023 outbreak, Tanzania 2024 outbreak, Rwanda 2025 outbreak, Tanzania
VP35
 I94V (A3224G)
 I94V (A3224G)
 I94V (A3224G)
VP40
 V57I (G4736)
 V57I (G4736), Q159R (5043G)
 V57I (G4736)
GP
 P234S (C6640T), Y279D (6775G), H349N (C6985), S389G (A7105G)
 P234S (C6640T), Y279D (6775G)
 P234S (C6640T), Y279D (6775G), E241G (A6662G), H349N (C6985), S389G (A7105G)
L I243L (A12207C), D699N (G13575A), V1673A (T16494C), M1734V (16680G), R1756S (A16748C), R1756S (A16748C) K174R (A12001G), V1673A (T16494C), R1756S (A16748C), S1820L (C16939T, T16940A), R1855K (G17044A)

*Study strains were compared with a reference isolate, GenBank accession number NC_001608.3. GP, glycoprotein; L, polymerase; VP, viral protein.

Main Article

1These first authors contributed equally to this article.

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Page updated: January 29, 2026
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