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Volume 32, Number 10—October 2026

CME ACTIVITY - Synopsis

Meta-analysis of Maternal and Fetal Outcomes of Crimean-Congo Hemorrhagic Fever during Pregnancy

Bahar Donk, Deniz Güllü, Ahmet Mirhan Cırık, Handan Alay, Faruk Karakeçili, Kemalettin Özden, Fatma Kesmez Can, Orçun Barkay, Natalia Pshenichnaya, and Önder ErgönülComments to Author 
Author affiliation: Graduate School of Health Sciences, Koç University, Istanbul, Turkey (B. Donk, D. Güllü); School of Medicine, Koç University, Istanbul (B. Donk, D. Güllü, Ö. Ergönül); Koç University—İşBank Center for Infectious Diseases (KUISCID), Istanbul (B. Donk, D. Güllü, Ö. Ergönül); School of Medicine, Marmara University, Istanbul (A.M. Cırık); School of Medicine, Atatürk University, Erzurum, Turkey (H. Alay, K. Özden, F.K. Can); School of Medicine, Binali Yıldırım University, Erzincan, Turkey (F. Karakeçili, O. Barkay); Central Research Institute of Epidemiology, Moscow, Russia (N. Pshenichnaya); Russian Medical Academy of Continuous Professional Education, Moscow, Russia (Ö. Ergönül)

Main Article

Table 2

Laboratory parameters of pregnant patients from a meta-analysis of maternal and fetal outcomes of Crimean-Congo hemorrhagic fever during pregnancy

Parameter No. patients Median patient value (IQR) Reference range
Leukocytes, × 103 cells/mL 34 3.7 (2.8–5.1) 4–11
Hemoglobin, g/dL 17 10.0 (9.0–11.1) 12–16
Platelet count, × 103/µL 35 58 (24–115) 150–400
Alanine aminotransferase, U/L 22 80 (25–190) 0–40
Aspartate aminotransferase, U/L 22 226.5 (56–448.5) 0–37
Lactate dehydrogenase, U/L 18 473.5 (262.5–1,004) 120–250
Creatinine phosphokinase, U/L 12 90 (70.8–962) 30–200
Prothrombin time, s 26 13.25 (11.4–15.0) 8.9–11.1
Activated partial thromboplastin time, s 26 43.5 (30.9–53.8) 24–35
International normalized ratio 13 1.07 (1.00–1.22) 0.8–1.2

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Page created: August 05, 2026
Page updated: September 28, 2026
Page reviewed: September 28, 2026
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