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Volume 32, Number 12—December 2026

Dispatch

Typhoid Fever–Like Manifestation of Scrub Typhus in Patient with Myelodysplastic Syndrome, China, 2025

Yu Li, Weihua Wang, Xuejun Gao, and Yu-feng GuComments to Author 
Author affiliation: Yantai Yuhuangding Hospital, Yantai, China

Main Article

Figure 1

Bone marrow morphology in samples from a 79-year-old man with scrub typhus and myelodysplastic syndrome, Shandong Province, China, 2025. A) High-power view showing a macrophage with abundant cytoplasm filled with fine eosinophilic granules (arrow), morphologically resembling the typhoid cells classically described in Salmonella enterica serovar Typhi bone marrow infection. B) A macrophage exhibiting phagocytosis of a neutrophil (arrow). The findings were initially interpreted as evidence of typhoid fever but were ultimately attributed to Orientia tsutsugamushi infection, confirmed by targeted next-generation sequencing. (\Wright-Giemsa stains; original magnification ×1,000.

Figure 1. Bone marrow morphology in samples from a 79-year-old man with scrub typhus and myelodysplastic syndrome, Shandong Province, China, 2025. A) High-power view showing a macrophage with abundant cytoplasm filled with fine eosinophilic granules (arrow), morphologically resembling the typhoid cells classically described in Salmonella enterica serovar Typhi bone marrow infection. B) A macrophage exhibiting phagocytosis of a neutrophil (arrow). The findings were initially interpreted as evidence of typhoid fever but were ultimately attributed to Orientia tsutsugamushi infection, confirmed by targeted next-generation sequencing. (\Wright-Giemsa stains; original magnification ×1,000.

Main Article

Page created: August 26, 2026
Page updated: October 23, 2026
Page reviewed: October 23, 2026
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