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Volume 32, Number 4—April 2026

Research

Dengue Incidence, Seroprevalence, and Expansion Factors from Active Surveillance, Brazil, 2016–2021

Eliana Nogueira Castro de Barros, Manuela de Almeida Roediger, Maïna L’Azou JacksonComments to Author , Morgan A. Marks, Elizabeth M. Anderson, Alejandra Esteves-Jaramillo, Germán Áñez, José A. Sousa Moreira, and Fernanda Castro Boulos
Author affiliation: Instituto Butantan, São Paulo, Brazil (E.N.C. Barros, M.A. Roediger, J.A.S. Moreira, F.C. Boulos); MSD (UK) Limited, London, UK (M. L'Azou Jackson); Merck & Co., Inc., Rahway, New Jersey, USA (M.A. Marks, E.M. Anderson, A. Esteves-Jaramillo, G. Áñez)

Main Article

Figure 4

Clinical manifestations of VCD and CHIKV among participants in the placebo arm of the DEN-03-IB trial of a live attenuated tetravalent dengue vaccine, Butantan-DV, Brazil, 2016–2021. Bars represent percentages of participants with each symptom; error bars represent 95% CIs. Numeric percentages are indicated for symptoms with >10% difference between VCD and CHIKV cases. VCD, virologically confirmed dengue; CHIKV, laboratory-confirmed chikungunya.

Figure 4. Clinical manifestations of VCD and CHIKV among participants in the placebo arm of the DEN-03-IB trial of a live attenuated tetravalent dengue vaccine, Butantan-DV, Brazil, 2016–2021. Bars represent percentages of participants with each symptom; error bars represent 95% CIs. Numeric percentages are indicated for symptoms with >10% difference between VCD and CHIKV cases. VCD, virologically confirmed dengue; CHIKV, laboratory-confirmed chikungunya.

Main Article

1Preliminary results from this study were presented at the American Society for Tropical Medicine and Hygiene annual meeting; November 13–17, 2024; New Orleans, Louisiana, USA.

Page created: February 27, 2026
Page updated: April 15, 2026
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