Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 32, Number 5—May 2026
Research Letter
Human Respiratory Syncytial Virus in Vaccinated and Unvaccinated Adults, Georgia, USA, 2024–2025
Saïd Rachida1, Alaa Ahmed1, Diana Rojas-Gallardo, Henok Tafesse, Hannah Dakanay, Mackenzie Duford, Collin Tolbert, Ryan S. Springfield, and Anne Piantadosi
Table
Amino acid mutations at antigenic sites in the RSV F protein for a study of human respiratory syncytial virus in vaccinated and unvaccinated adults, Georgia, USA, 2024–2025*
| Antigenic site | RSV-A |
RSV-B |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Unvaccinated, n = 58 |
Vaccinated, n = 7 |
Unvaccinated, n = 53 |
Vaccinated, n = 6 |
||||||
| Sub. |
No. (%) |
Sub. |
No. (%) |
Sub. |
No. (%) |
Sub. |
No. (%) |
||
| Site ϕ, 62–96, 195–227 | T72I | 1 (2) | K65R | 1 (20) | N63S | 1 (2) | I206M | 6 (100) | |
| I206M | 53 (100) | Q209R | 5 (83) | ||||||
| Q209R | 52 (98) | S211N | 6 (100) | ||||||
| S211N |
53 (100) |
||||||||
| Site I, 27–45, 312–318, 378–389 | I379V | 58 (100) | I379 | 7 (100) | R42K | 25 (47) | R42K | 2 (33%) | |
| V384I | 58 (100) | V384I | 6 (80) | F54L | 53 (100) | F54L | 6 (100) | ||
| S389P |
50 (94) |
S389P |
(67) |
||||||
| Site II, (254–277) |
N276S |
33 (57) |
N276S |
4 (57) |
ND |
ND |
ND |
ND |
|
| Site III, 46–54, 301–311, 345–352, 367–378 |
S377N |
3 (5) |
S377N |
3 (43) |
ND |
ND |
ND |
ND |
|
| Site IV, 422–471 | M447V | 58 (100) | M447V | 7 (100) | K445R | 1 (2) | ND | ND | |
| K470R |
2 (3) |
N466S |
1 (2) |
||||||
| Site V, 55–61, 146–194, 287–300 | I59V | 5 (7) | V152I | 7 (100) | L172Q | 53 (100) | L172Q | 6 (100) | |
| V152I | 58 (100) | L178V | 7 (100) | S173L | 53 (100) | S173L | 6 (100) | ||
| V154I | 1 (2) | S190N | 52 (98) | S190N | 6 (98) | ||||
| L178V | 58 (100) | K191R | 53 (100) | K191R | 6 (100) | ||||
*Sub., substitution; RSV, respiratory syncytial virus.
1These authors contributed equally to this article.
Page created: April 28, 2026
Page updated: May 04, 2026
Page reviewed: May 04, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.