Volume 32, Number 5—May 2026
Research Letter
Human Respiratory Syncytial Virus in Vaccinated and Unvaccinated Adults, Georgia, USA, 2024–2025
Saïd Rachida1, Alaa Ahmed1, Diana Rojas-Gallardo, Henok Tafesse, Hannah Dakanay, Mackenzie Duford, Collin Tolbert, Ryan S. Springfield, and Anne Piantadosi
Table
Amino acid mutations at antigenic sites in the RSV F protein for a study of human respiratory syncytial virus in vaccinated and unvaccinated adults, Georgia, USA, 2024–2025*
| Antigenic site |
RSV-A |
RSV-B |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Unvaccinated, n = 58 |
Vaccinated, n = 7 |
Unvaccinated, n = 53 |
Vaccinated, n = 6 |
||||||||
| Sub. |
No. (%) |
Sub. |
No. (%) |
Sub. |
No. (%) |
Sub. |
No. (%) |
||||
| Site ϕ, 62–96, 195–227 | T72I | 1 (2) | K65R | 1 (20) | N63S | 1 (2) | I206M | 6 (100) | |||
| I206M | 53 (100) | Q209R | 5 (83) | ||||||||
| Q209R | 52 (98) | S211N | 6 (100) | ||||||||
| S211N |
53 (100) |
||||||||||
| Site I, 27–45, 312–318, 378–389 | I379V | 58 (100) | I379 | 7 (100) | R42K | 25 (47) | R42K | 2 (33) | |||
| V384I | 58 (100) | V384I | 6 (80) | F54L | 53 (100) | F54L | 6 (100) | ||||
| S389P |
50 (94) |
S389P |
4 (67) |
||||||||
| Site II, 254–277 |
N276S |
33 (57) |
N276S |
4 (57) |
ND |
ND |
ND |
ND |
|||
| Site III, 46–54, 301–311, 345–352, 367–378 |
S377N |
3 (5) |
S377N |
3 (43) |
ND |
ND |
ND |
ND |
|||
| Site IV, 422–471 | M447V | 58 (100) | M447V | 7 (100) | K445R | 1 (2) | ND | ND | |||
| K470R |
2 (3) |
N466S |
1 (2) |
||||||||
| Site V, 55–61, 146–194, 287–300 | I59V | 5 (7) | V152I | 7 (100) | L172Q | 53 (100) | L172Q | 6 (100) | |||
| V152I | 58 (100) | L178V | 7 (100) | S173L | 53 (100) | S173L | 6 (100) | ||||
| V154I | 1 (2) | S190N | 52 (98) | S190N | 6 (98) | ||||||
| L178V | 58 (100) | K191R | 53 (100) | K191R | 6 (100) | ||||||
*Sub., substitution; RSV, respiratory syncytial virus.
1These authors contributed equally to this article.
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Page updated: May 08, 2026
Page reviewed: May 08, 2026
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