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Volume 32, Number 6—June 2026

Research

Characteristics of Plausible Source Cases Responsible for Recent Mycobacterium tuberculosis Transmission, United States, 2018–2022

Steve Kammerer, Daniel Flanagan, Kala Raz, Tambi Shaw, Jonathan Wortham, and Sarah TalaricoComments to Author 
Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Kammerer, K. Raz, J. Wortham, S. Talarico); Emory University, Atlanta (D. Flanagan); California Department of Public Health, Richmond, California, USA (T. Shaw)

Main Article

Figure 2

Flow diagram showing selection of recent transmission source–secondary case pairs from 50 states and Washington, DC, included in an analysis of plausible source cases responsible for recent Mycobacterium tuberculosis transmission, United States, 2018–2022. Among 3,762 RT case pairs identified, case pairs with >5 SNP differences were excluded (n = 1,840), leaving 1,922 WGS–validated RT case pairs. The analytic dataset included 922 TB cases attributed to RT during 2020–2022 and plausible source cases identified during 2018–2020 (all plausible source cases [n = 893] and most likely plausible source cases [n = 645]). RT, recent transmission; SNP, single-nucleotide polymorphism; TB, tuberculosis; WGS, whole-genome sequencing.

Figure 2. Flow diagram showing selection of recent transmission source–secondary case pairs from 50 states and Washington, DC, included in an analysis of plausible source cases responsible for recent Mycobacterium tuberculosis transmission, United States, 2018–2022. Among 3,762 RT case pairs identified, case pairs with >5 SNP differences were excluded (n = 1,840), leaving 1,922 WGS–validated RT case pairs. The analytic dataset included 922 TB cases attributed to RT during 2020–2022 and plausible source cases identified during 2018–2020 (all plausible source cases [n = 893] and most likely plausible source cases [n = 645]). RT, recent transmission; SNP, single-nucleotide polymorphism; TB, tuberculosis; WGS, whole-genome sequencing.

Main Article

Page created: April 13, 2026
Page updated: June 01, 2026
Page reviewed: June 01, 2026
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