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Volume 32, Number 7—July 2026

Historical Review

Discovery of Cinchona as Antimalarial, Viceroyalty of Peru, Circa 1630

Jesús Rojas-JaimesComments to Author , Stephanie Rodríguez-Gómez, and Guido P. Lombardi
Author affiliation: Universidad Privada del Norte, Lima, Peru (J. Rojas-Jaimes); Universidad Científica del Sur, Lima (J. Rojas-Jaimes); Universidad Continental, Lima (J. Rojas-Jaimes); Universidad Nacional Federico Villarreal, Lima (S. Rodríguez-Gómez); Universidad Peruana Cayetano Heredia, Lima (G.P. Lombardi)

Main Article

Figure 2

Documents from 1768 in archives of 2 very important locations for the Viceroyalty of Peru (Cuzco and Lima in present-day Peru) referring to “cascarilla powder” and “Loja powder” A) “Cascarilla powder” is mentioned in the Archive of the Colegio Ciencias: File 6, book 1, page 112, Cuzco. 1768–1769 (21). B) Page of the inventory of the apothecary of Saint Paul's College, where “Loja’s powders of cinchona” is mentioned. Source: Velada R. National Archives of Peru, 1768 (22).

Figure 2. Documents from 1768 in archives of 2 very important locations for the Viceroyalty of Peru (Cuzco and Lima in present-day Peru) referring to “cascarilla powder” and “Loja powder” A) “Cascarilla powder” is mentioned in the Archive of the Colegio Ciencias: File 6, book 1, page 112, Cuzco. 1768–1769 (21). B) Page of the inventory of the apothecary of Saint Paul's College, where “Loja’s powders of cinchona” is mentioned. Source: Velada R. National Archives of Peru, 1768 (22).

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References
  1. Brack  A. The Peruvian bark that saved millions of lives. A brief history of cinchona and quinine [in Spanish]. 1st edition. Lima (Peru): Powerful Mining Company; 2021.
  2. Epiquién  MA. Natural bicentennials. Stories of cinchona trees and vicuñas [in Spanish]. 1st edition. Lima (Peru): Black Box Publishing Group; 2021.
  3. Haggis  AW. Fundamental errors in the early history of Cinchona. Bull Hist Med. 1941;10:41759 https://archive.org/details/b2982381x cited 2026 Jun 8.
  4. Chakrabarti  P. Empire and alternatives: Swietenia febrifuga and the cinchona substitutes. Med Hist. 2010;54:7594. DOIPubMedGoogle Scholar
  5. Rieckmann  KH. The chequered history of malaria control: are new and better tools the ultimate answer? Ann Trop Med Parasitol. 2006;100:64762. DOIPubMedGoogle Scholar
  6. Lowe  D. Chloroquine, past and present. Science. 2020 Mar 20 [cited 2026 Apr 10]. https://www.science.org/content/blog-post/chloroquine-past-and-present
  7. Slater  AFG, Cerami  A. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature. 1992;355:1679. DOIPubMedGoogle Scholar
  8. Karle  JM, Karle  IL, Gerena  L, Milhous  WK. Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum. Antimicrob Agents Chemother. 1992;36:153844. DOIPubMedGoogle Scholar
  9. Laval  E. Pharmacy of the Jesuits of Santiago [in Spanish]. 1st edition. Santiago (Chile): Stanley; 1953 [cited 2026 Jun 8]. https://www.memoriachilena.gob.cl/602/w3-article-62244.html
  10. Ortiz  F. Monardes and Fragoso: two 16th-century protobotanists who dealt with New World plants and the implications of their writings on the European introduction of “quina” (cinchona) tree bark. In: Rios M, y Borgtoft H, editors. Use and management of plant resources: proceedings of the Second Ecuadorian Symposium on Ethnobotany and Economic Botany [in Spanish]. First edition. Quito (Ecuador): Abya-Yala; 1997. p. 347–60.
  11. Calancha  A. Moralized chronicle of the order of Saint Augustine in Perú [in Spanish]. 1639 [cited 2026 Jun 8]. https://estudiosindianos.up.edu.pe/en/biblioteca-indiana/coronica-moralizada-del-orden-de-san-agustin-en-el-peru
  12. Bado  S. Anastasis of the bark of Perú, or defense of the china-china [in Latin]. 1663 [cited 2026 Jun 8]. https://archive.org/details/Be.XVII.A.613.2.
  13. Guerra  F. The introduction of Cinchona in the treatment of malaria. Part I. J Trop Med Hyg. 1977;80:1128.PubMedGoogle Scholar
  14. Lopez  JM, Calero  F. On the febrifuge powder of the West Indies (1663) de Gaspar Caldera de Heredia and the introduction of quinine in Europe [in Spanish]. 1st edition. Valencia (Spain): Universidad de Valencia; 1992 [cited 2025 July 27]. https://digital.csic.es/bitstream/10261/90526/1/XXXIX_Pulvere_Febrifugo.pdf
  15. Cobo  B. Works of Father Bernabé Cobo [in Spanish]. 1st edition. Madrid: Atlas Editions; 1964.
  16. Augusto  E. Quinine in Peru [in Spanish]. 1st edition. Tambopata (Peru): Permanent Commission of Quina; 1943.
  17. Anda Aguirre  A. Quinine or cascarilla in Loja [in Spanish]. 1st edition. Loja (Ecuador): Editorial Office of the Private Technical University of Loja; 2002.
  18. Estrella  E. Enlightened science and popular knowledge in the understanding of quinine in the 18th century [in Spanish]. In: Cueto M, editor. Andean knowledge: science and technology in Bolivia, Ecuador, and Peru [in Spanish]. Lima (Peru): Institute of Peruvian Studies; 1995. p. 3757.
  19. De Jussieu  J. Description of the cinchona tree [in French]. 1st edition. Paris: Company for the Processing of Cinchonas; 1936.
  20. Arias  J. Barks of hope [in Spanish]. 1st edition. Loja (Ecuador): Hernandez Graphics; 2017.
  21. Archive College of Sciences. File 6, notebook 1, shelves 112 [in Spanish]. Cuzco (Peru). 1768–1769, file 6.
  22. Velada  R. Inventory of the pharmacy of the Saint Paul’s College, made as a result of the expatriation of the Fathers of the Society of Jesus [in Spanish]. Lima (Peru): National Archives of Peru; 1768.
  23. Santisteban  M. A thousand leagues through America. From Lima to Caracas, 1740–1741. Diary of Don Miguel de Santisteban [in Spanish]. Bogotá (Columbia): Bank of the Republic; 1992.
  24. Cuvi  N. Science and imperialism in Latin America: the Chinchona misión and the cooperative agricultural stations [in Spanish]. 1st edition. Barcelona (Spain): Autonomous University of Barcelona; 2009 [cited 2026 Jun 8]. http://www.tdx.cat/TDX-0121110-151121
  25. García  L, Veneros  J, Chavez  SG, Oliva  M, Rojas-Briceño  NB. World historical mapping and potential distribution of Cinchona spp. in Peru as a contribution for its restoration and conservation. J Nat Conserv. 2022;70:126290. DOIGoogle Scholar
  26. Ireland  KB, Kriticos  DJ. Why Are plant pathogens under-represented in eco-climatic niche modelling? Int J Pest Manag. 2019;65:20716. DOIGoogle Scholar
  27. Griffing  SM, Gamboa  D, Udhayakumar  V. The history of 20th century malaria control in Peru. Malar J. 2013;12:303. DOIPubMedGoogle Scholar
  28. Ramírez  SE. The world upside down: cross-cultural contact and conflict in sixteenth-century Peru. Stanford (California): Stanford University Press; 1996.
  29. Foster  GM. Hippocrates’ Latin American legacy: “hot” and “cold” in contemporary folk medicine. In: Wetherington R, editor. Colloquia in anthropology, volume 2. Dallas: Southern Methodist University, Fort Burgwin Research Center; 1978. p. 319.
  30. Allison  MJ, Pezzia  A, Gerszten  E, Mendoza  D. A case of Carrion’s disease associated with human sacrifice from the Huari culture of Southern Peru. Am J Phys Anthropol. 1974;41:295300. DOIPubMedGoogle Scholar
  31. Michel  M, Skourtanioti  E, Pierini  F, Guevara  EK, Mötsch  A, Kocher  A, et al. Ancient Plasmodium genomes shed light on the history of human malaria. Nature. 2024;631:12533. DOIPubMedGoogle Scholar
  32. Albis  MM. The Indians of Andaqui, New Granada. Notes of a traveler (Translated from the Spanish by J.S. Thrasher under the J.M. Vergara y Vergara & E. Delgado supervision). Bull. Am Ethnological Soc. 1855;1:5372.
  33. De Carvajal G, Toribio J, editors. Discovery of the Amazon River according to the hitherto unpublished account of the voyage of Francisco de Orellana [in Spanish]. Seville (Spain): E. Rasco Printing House; 1894.
  34. Simón  P. The expedition of Pedro de Ursua & Lope de Aguirre in search of El Dorado and Omagua in 1560–1. Cambridge: Cambridge University Press; 2010. DOIGoogle Scholar
  35. Cooper  P, Guderian  R, Paredes  W, Daniels  R, Perera  D, Espinel  M, et al. Bartonellosis in Zamora Chinchipe province in Ecuador. Trans R Soc Trop Med Hyg. 1996;90:2413, 544–6. DOIPubMedGoogle Scholar
  36. Legua  LP. Malaria in Perú [in Spanish]. Heredian Medical Journal 2013;5(3) [cited 2025 Oct 19]. https://revistas.upch.edu.pe/index.php/RMH/article/view/436
  37. Church WB, Von Hagen AC, Silverman H, Isbell WH, editors. Handbook of South American archaeology. New York: Springer; 2008.
  38. Austin Alchon  S. A pest in the land: New World epidemics in a global perspective. Albuquerque (NM): University of New Mexico Press; 2003.
  39. Bussmann  RW, Sharon  D. Traditional medicinal plant use in Loja Province, southern Ecuador. J Ethnobiol Ethnomed. 2006;2:44. DOIPubMedGoogle Scholar
  40. Aguilar  CA, Xolalpa  MS. Mexican herbal medicine in the treatment of diabetes [in Spanish]. Science (Mexico). 2002;53:2435.
  41. Jaramillo Alvarado. Pío. History of Loja and its province [in Spanish]. 4th edition. Guayaquil (Ecuador): Artes Gráficas Senefelder; 2001.
  42. Hernadez  E. The Piura elite and the independence of Peru: the struggle for continuity in the nascent republic (1750–1824) [in Spanish]. Lima (Peru): University of Piura, Riva–Agüero Institute; 2008.
  43. Hernádez  E. The Sánchez Navarrete and González de Salazar: a powerful family in the port of Paita in the second half of the 18th century [in Spanish]. Complutense Journal of American History. 2008;34:183207.
  44. General Archive of the Indies of Seville [in Spanish]. Quito (Ecuador). 246 No. 48. Year 1788. Fol. 9.
  45. Hernadez  E. The Piura elite and the independence of Peru: the struggle for continuity in the nascent republic (1750–1824) [in Spanish]. Lima (Peru): University of Piura, Riva-Agüero Institute; 2008.
  46. Arias  JC. Historic Loja [in Spanish]. First edition. Loja (Ecuador): International Congress of History; 2016 [cited 2024 Dec 23]. https://biblioteca.culturaypatrimonio.gob.ec/cgi-bin/koha/opac-detail.pl?biblionumber=248041
  47. Departmental Archive of Piura, Cabildo, civil cases, leg. 8 exp. 154 [in Spanish]. 1796.
  48. General Archive of the Nation. account Books, c15, leg. 177, exp. 880 [in Spanish]. 1796 [cited 2024 Dec 23]. https://fondosdocumentales.agn.gob.pe/index.php.
  49. Monardes  N. First, second, and third parts of the medicinal history of things brought from our West Indies [in Spanish]. First edition. 1574 [cited 2026 Jun 8]. https://estudiosindianos.up.edu.pe/en/biblioteca-indiana/primera-y-segunda-y-tercera-partes-de-la-historia-medicinal-de-las-cosas-que-se-traen-de-nuestras-indias-occidentales-de-nicolas-monardes
  50. Lefebvre  MJM, Degrugillier  F, Arnathau  C, Fontecha  GA, Noya  O, Houzé  S, et al. Genomic exploration of the journey of Plasmodium vivax in Latin America. PLoS Pathog. 2025;21:e1012811. DOIPubMedGoogle Scholar

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Page created: June 09, 2026
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