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Volume 32, Number 8—August 2026

Research Letter

Antibodies Cross-Reactive with Bundibugyo Virus in Ferrets Vaccinated with Ebola Virus Vaccine

Jordan Wight, Helene Schulz, and Logan BanadygaComments to Author 
Author affiliation: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (J. Wight, H. Schulz, L. Banadyga); University of Manitoba, Winnipeg (L. Banadyga)

Main Article

Figure 2

Endpoint titers of EBOV glycoprotein– and BDBV glycoprotein–specific IgG in rVSV-EBOV– vaccinated ferrets and controls in study of antibodies cross-reactive with BDBV in ferrets vaccinated with EBOV vaccine. Serial dilutions of serum were assayed by indirect ELISA. Date shown are reciprocal endpoint titers exceeding the cut-off value of the mean plus 3 times the SD of the 1:400 dilution of prevaccination serum collected from all ferrets. Horizontal colored lines represent the mean reciprocal endpoint titers. The dashed line at a reciprocal endpoint titer of 400 represents the lower limit of detection of the assay. BDBV, Bundibugyo virus; EBOV, Ebola virus; rVSV-EBOV, recombinant vesicular stomatitis virus–based vaccine encoding the Ebola virus glycoprotein.

Figure 2. Endpoint titers of EBOV glycoprotein– and BDBV glycoprotein–specific IgG in rVSV-EBOV– vaccinated ferrets and controls in study of antibodies cross-reactive with BDBV in ferrets vaccinated with EBOV vaccine. Serial dilutions of serum were assayed by indirect ELISA. Date shown are reciprocal endpoint titers exceeding the cut-off value of the mean plus 3 times the SD of the 1:400 dilution of prevaccination serum collected from all ferrets. Horizontal colored lines represent the mean reciprocal endpoint titers. The dashed line at a reciprocal endpoint titer of 400 represents the lower limit of detection of the assay. BDBV, Bundibugyo virus; EBOV, Ebola virus; rVSV-EBOV, recombinant vesicular stomatitis virus–based vaccine encoding the Ebola virus glycoprotein.

Main Article

Page created: June 11, 2026
Page updated: June 24, 2026
Page reviewed: June 24, 2026
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