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Volume 5, Number 1—February 1999


Socioeconomic and Behavioral Factors Leading to Acquired Bacterial Resistance to Antibiotics in Developing Countries

Iruka N. Okeke*, Adebayo Lamikanra*, and Robert Edelman†Comments to Author 
Author affiliations: *Obafemi Awolowo University, Ile-Ife, Nigeria;; †University of Maryland School of Medicine, Baltimore, Maryland, USA

Main Article

Table 2

Source and quality of tetracycline capsules in a Nigerian suburban town (compiled with data from [53])

Sample Source Tetracycline content (% of label claim) Content of ATCa (%) Bioavailability (%)b
C1 Manufacturerc 105.9 None detected 100
C2 Hospital 107.5 5.3 63.4d
C3 Roadside stall 104.5 1.1 80.5d
C4 Pharmacy 66.1 2.4 65.2d
C5 Patent medicine stall 84.5 1.9 87.6d
C6 Roadside stall 67.8 1.5 Not tested
C7 Patent medicine stall 89.6 1.8 Not tested

aAnhydrotetracycline, one of four tetracycline degradation products.
bMeasured from cumulative excretion of tetracycline in the urine of five volunteers.
cReference standard obtained from the manufacturer.
dSignificantly different from C1 (p = 0.01, Wilcoxon signed rank test).

Main Article