Figure 3. Four options for responding to an influenza pandemic: mean net economic returns. Notes: a) Bars show mean net returns for each option and assumed cost of vaccination. b) Option A: Similar to current Advisory Committee on Immunization Practices recommendations, with production and use similar to current, intra-pandemic recommendations (17). Assumed approximately 77 million vaccinees. Option B: Number of vaccinees as outlined in Scenario A plus 20 million essential service providers (5 million health-care workers + 15 million other service providers). Option C: Aim to achieve a 40% coverage of total U.S. population. Option D: Aim to achieve 60% coverage of total U.S. population (Appendix 2).