Volume 7, Number 3—June 2001
Perspective
Seasonal Variation in Host Susceptibility and Cycles of Certain Infectious Diseases
Table
Observations on the seasonal occurrence of infectious diseases
Observation | Examples |
---|---|
Pathogens peak at characteristic times in all seasons of the year | Winter: influenza, pneumococcus, rotavirus Spring: RSV, measles Summer: polio, other enteroviruses Fall: parainfluenza virus type 1 |
Timing and duration of peaks for each pathogen are similar from year to year | Measles: regular pattern since 1703 (1) Influenza: annual peak varies by only 5 to 10 weeks in the United States (6) |
Onset of epidemics often occurs simultaneously in areas that are geographically dispersed and have different weather conditions and diverse populations | Influenza: simultaneous outbreaks across North America, 16 European countries, and 6 Chinese provinces (7) Pneumococcus: simultaneous outbreaks in seven surveillance areas (8) |
Latitude is a critical determinant of timing and magnitude of peaks | An increasing magnitude of seasonal peaks as distance from the equator increases has been documented for polio (9) and rotavirus (10) and reported for influenza (11). |
Pathogens can be detected in the off-season despite lower incidence of disease and virtual absence of epidemics | Meningococcus: no decrease in carriage in the off-season, despite absence of epidemic disease (12) RSV: sporadic summer viral isolation but no epidemic spread (13) Influenza: sporadic summer isolation, occasional clusters of disease without epidemic spread (14) |
RSV = respiratory syncytial virus. RSV peaks in the winter or spring in the United States, depending on location. For simplicity, it is listed here as a spring pathogen.
References
- Brownlee J. An investigation into the periodicity of measles epidemics in London from 1703 to the present day by the method of the periodogram. Philosophical Transactions of the Royal Society of London 1918;B 208:225-50.
- Witte JJ, Karchmer A, Case M, Herrmann KL, Abrutyn E, Kassanoff I, Epidemiology of rubella. Am J Dis Child. 1969;118:107–11.PubMed
- Török TJ, Kilgore PE, Clarke MJ, Holman RC, Bresee JS, Glass RI. Visualizing geographic and temporal trends in rotavirus activity in the United States, 1991 to 1996. National Respiratory and Enteric Virus Surveillance System Collaborating Laboratories. Pediatr Infect Dis J. 1997;16:941–6.PubMed
- Centers for Disease Control and Prevention. Update: Influenza activity--United States, 1999-2000 season. MMWR Morb Mortal Wkly Rep. 2000;49:173–7.PubMed
- Centers for Disease Control and Prevention. Update: Influenza activity--United States and worldwide, 1995-96 season, and composition of the 1996-97 influenza vaccine. MMWR Morb Mortal Wkly Rep. 1996;45:326–9.PubMed
- Dowell SF, Whitney C, Wright C, Schuchat A. Seasonal changes in invasive pneumococcal disease. Emerg Infect Dis. 2001. In press.PubMed
- Paccaud MF. World trends in poliomyelitis morbidity and mortality, 1951-1975. World Health Stat Q. 1979;32:198–224.PubMed
- Cook SM, Glass R, LeBaron C, Ho M-S. Global seasonality of rotavirus infections. Bull World Health Organ. 1990;68:171–7.PubMed
- Centers for Disease Control and Prevention. Update: respiratory syncytial virus activity - United States, 1998-1999 Season. MMWR Morb Mortal Wkly Rep. 1999;48:1104–15.PubMed
- Checkley W, Epstein L, Gilman R, Figueroa D, Cama RI, Patz JA. Effects of El Niño and ambient temperature on hospital admissions for diarrheal diseases in Peruvian children. Lancet. 2000;355:442–50.PubMed
- Nathanson N, Martin J. The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidemicity, and disappearance. Am J Epidemiol. 1979;110:672–92.PubMed
- Greenwood B. The epidemiology of acute bacterial meningitis in tropical Africa. Bacterial Meningitis. London: Academic Press; 1987. p. 61-91.
- D'Alessio D, Minor T, Allen C, Tsiatis A, Nelson D. A study of the proportions of swimmers among well controls and children with enterovirus-like illness shedding or not shedding an enterovirus. Am J Epidemiol. 1981;113:533–41.PubMed
- Hamer W. Epidemic disease in England--the evidence of variability and persistency of type. Lancet. 1906;11:733–9.
- Rojansky N, Brzezinski A, Schenker J. Seasonality in human reproduction: an update. Hum Reprod. 1992;7:735–45.PubMed
- Wehr TA, Moul D, Barbato G, Giesen HA, Seidel JA, Barker C, Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol. 1993;265:R846–57.PubMed
- Chan PJ, Hutz R, Dukelow W. Nonhuman primate in vitro fertilization: seasonality, cumulus cells, cyclic nucleotides, ribonucleic acid, and viability assays. Fertil Steril. 1982;38:609–15.PubMed
- Yellon SM, Fagoaga O, Nehlsen-Cannarella S. Influence of photoperiod on immune cell functions in the male Siberian hamster. Am J Physiol. 1999;276:R97–102.PubMed
- Wongwiwat M, Sukapanit S, Triyanond C, Sawyer WD. Circadian rhythm of the resistance of mice to acute pneumococcal infection. Infect Immun. 1972;5:442–8.PubMed
- Ownby HE, Frederick J, Mortensen R, Ownby D, Russo J. Seasonal variations in tumor size at diagnosis and immunological responses in human breast cancer. Invasion Metastasis. 1986;6:246–56.PubMed
- Paigen B, Ward E, Reilly A, Houten L, Gurtoo HL, Minowada J, Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes. Cancer Res. 1981;41:2757–61.PubMed
- Shadrin AS, Marinich I, Taros L. Experimental and epidemiological estimation of seasonal and climato-geographical features of non-specific resistance of the organism to influenza. J Hyg Epidemiol Microbiol Immunol. 1977;21:155–61.PubMed
- World Health Organization Collaborative Study Group on Oral Poliovirus V. Factors affecting the immunogenicity of oral poliovirus vaccine: a prospective evaluation in Brazil and the Gambia. J Infect Dis. 1995;171:1097–106.PubMed
- Schonberger LB, McGowan JJ, Gregg M. Vaccine-associated poliomyelitis in the United States, 1961-1972. Am J Epidemiol. 1976;104:202–11.PubMed
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