Volume 7, Number 3—June 2001
Research
Molecular Epidemiology of Serogroup A Meningitis in Moscow, 1969 to 1997
Mark Achtman*
, Arie van der Ende†, Peixuan Zhu*, Irina S. Koroleva‡, Barica Kusecek*, Giovanna Morelli*, Ilse G.A. Schuurman†, Norbert Brieske*, Kerstin Zurth*, Natalya N. Kostyukova§, and Alexander E. Platonov‡
, Arie van der Ende†, Peixuan Zhu*, Irina S. Koroleva‡, Barica Kusecek*, Giovanna Morelli*, Ilse G.A. Schuurman†, Norbert Brieske*, Kerstin Zurth*, Natalya N. Kostyukova§, and Alexander E. Platonov‡
Table 1
Multilocus sequence typing analysis of serogroup A meningococci
| STa | MLEE/ RAPD | Sources | No. | fumC | abcZ | adk | aroE | gdh | pdhC | pgm |
|---|---|---|---|---|---|---|---|---|---|---|
| 21 | other | UK (1941) | 1 | 1 | 1 | 5 | 1 | 2 | 16 | 17 |
| 1 | I, II | Pandemic (1963-80) | 15 | 1 | 1 | 3 | 1 | 1 | 1 | 3 |
| 75 | X | Moscow (1983-94) | 3 | 1 | 2 | 3 | 25 | 1 | 1 | 3 |
| 78 | X | Moscow (1997) | 1 | 1 | 2 | 3 | 25 | 1 | 1 | 17 |
| 76 | X | Moscow (1983-85) | 4 | 17 | 2 | 3 | 1 | 1 | 1 | 3 |
| 77 | X | Moscow (1984-85) | 3 | 1 | 2 | 3 | 1 | 1 | 1 | 3 |
| 69 | VI | Moscow (1970) | 1 | 28 | 1 | 3 | 4 | 1 | 1 | 3 |
| 2 | VI | Moscow, GDR (1980-95) | 17 | 7 | 1 | 3 | 4 | 1 | 1 | 3 |
| 68 | VI | Moscow (1994-96) | 2 | 7 | 1 | 3 | 4 | 21 | 1 | 17 |
| 70 | VI | Moscow (1984-86) | 2 | 7 | 1 | 3 | 4 | 22 | 21 | 3 |
| 73 | VI | Moscow (1995) | 1 | 7 | 1 | 3 | 4 | 1 | 21 | 3 |
| 58 | VI | GDR (1986) | 1 | 7 | 1 | 3 | 21 | 1 | 1 | 3 |
| 71 | VI | Moscow (1985) | 1 | 7 | 1 | 3 | 10 | 1 | 1 | 3 |
| 72 | VI | Moscow (1987) | 1 | 7 | 1 | 3 | 7 | 1 | 1 | 3 |
| 57 | II | USA (1930-43) | 2 | 1 | 1 | 3 | 1 | 1 | 2 | 3 |
| 4 | IV-1, IV-2 | Pandemic (1917-90) | 37 | 1 | 1 | 3 | 3 | 4 | 2 | 3 |
| 80 | Gambia (1983) | 1 | 31 | 1 | 3 | 15 | 4 | 2 | 3 | |
| 203 | Gambia (1996) | 1 | 1 | 1 | 3 | 2 | 3 | 2 | 3 | |
| 5 | III, VIII | Pandemic (1963-98) | 24 | 1 | 1 | 1 | 2 | 3 | 2 | 3 |
| 6 | III | China (1966) | 1 | 1 | 1 | 1 | 2 | 3 | 2 | 11 |
| 7 | III | Pandemic (1992-96) | 9 | 1 | 1 | 1 | 2 | 3 | 2 | 19 |
| 3 | V, VII | China (1963-87) | 11 | 1 | 1 | 3 | 1 | 1 | 23 | 13 |
| 59 | V | China (1980) | 1 | 22 | 1 | 14 | 1 | 1 | 23 | 13 |
| 103 | Greece (1996) | 1 | 17 | 8 | 4 | 6 | 5 | 18 | 2 | |
| 60 | IX | Holland (1989-92) | 4 | 17 | 17 | 5 | 19 | 3 | 26 | 2 |
| 61 | IX | Holland (1992) | 1 | 17 | 17 | 10 | 19 | 3 | 26 | 2 |
| 79 | other | Moscow (1995) | 1 | 26 | 12 | 5 | 6 | 9 | 22 | 8 |
| 299 | Czechoslovakia (1972) | 1 | 26 | 2 | 29 | 36 | 26 | 18 | 20 | |
| 300 | Czechoslovakia (1972) | 1 | 26 | 2 | 29 | 9 | 26 | 18 | 20 | |
| 388 | Czechoslovakia (1972) | 2 | 35 | 57 | 2 | 2 | 6 | 68 | 12 | |
| 400 | Czechoslovakia (1972) | 1 | 43 | 12 | 16 | 2 | 3 | 37 | 7 |
aST = sequence type; GDR = German Democratic Republic (East Germany); MLEE = multilocus enzyme electrophoresis; RAPD = random amplification of polymorphic DNA.
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