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Volume 7, Number 3—June 2001
Dispatch

Expanding Drug Resistance through Integron Acquisition by IncFI Plasmids of Salmonella enterica Typhimurium

Alessandra Carattoli*Comments to Author , Laura Villa*, Cristina Pezzella*, Eugenio Bordi†, and Paolo Visca†‡
Author affiliations: *Istituto Superiore di Sanità, Rome, Italy; †National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy; ‡Università di Roma Tre, Rome, Italy

Main Article

Table

Designation and relevant characteristics of representative IncFI plasmids used for genetic analysis of integrons

No. Plasmid Host strain Origin, yeara Resistance patternb Trac kb Ref.
1 IncFI/97 ST 366 Albania, 1997 Ap Cm Sm Sp Su Tc Hg Km Tp + 120 7
2 NTP101 ST DT 208 England, 1974 Ap Cm Sm Sp Su Tc Hg - 135 3
3 pZM3 SW 20 Algeria, 1970 Ap Cm Sm Sp Su Tc Hg Km + 165 10
4 TP181 ST DT 208 Iran, 1975 Ap Cm Sm Sp Su Tc Hg Km + 165 3
5 pZM111 SW WZM111 Italy, 1978 Ap Cm Hg Km Gm + 130 5
6 PZM61 SW WZM6 Italy, 1974 Ap Cm Tc Hg Km - 145 11

a Year of isolation.
b Abbreviations: Ap = ampicillin; Cm = chloramphenicol; Sm = streptomycin; Sp = spectinomycin; Su = sulfonamides; Tc = tetracycline; Hg = mercuric ions; Km = kanamycin; Tp = trimethoprim; Gm = gentamicin.
cAutotransferring properties.

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References
  1. Glynn  MK, Bopp  C, Dewitt  W, Dabney  P, Mokhtar  M, Angulo  FJ. Emergence of multidrug-resistant Salmonella enterica serotype Typhimurium DT104 infections in the United States. N Engl J Med. 1998;338:1333–8. DOIPubMedGoogle Scholar
  2. Prager  R, Liesegang  A, Rabsch  W, Gericke  B, Thiel  W, Voigt  W, Clonal relationship of Salmonella enterica serovar Typhimurium phage type DT104 in Germany and Austria. Zentralbl Bakteriol. 1999;289:399–414. DOIPubMedGoogle Scholar
  3. Anderson  ES, Threlfall  EJ, Carr  JM, McConnell  MM, Smith  HR. Clonal distribution of resistance plasmid-carrying Salmonella typhimurium, mainly in the Middle East. J Hyg (Lond). 1977;79:425–48. DOIPubMedGoogle Scholar
  4. Domart  A, Robineau  M, Stroh  A, Dubertret  LM, Modai  J. Septicemia due to Salmonella wien. Diagnostic, therapeutic and epidemiologic problems. Ann Med Interne (Paris). 1974;125:915–8.PubMedGoogle Scholar
  5. Casalino  MA, Comanducci  A, Nicoletti  M, Maimone  F. Stability of plasmid content in Salmonella wien in late phases of the epidemic history. Antimicrob Agents Chemother. 1984;25:499–501.PubMedGoogle Scholar
  6. Frost  JA, Rowe  B, Ward  LR, Threlfall  EJ. Characterization of resistance plasmids and carried phages in an epidemic clone of multi-resistant Salmonella typhimurium in India. J Hyg (Lond). 1982;88:193–204. DOIPubMedGoogle Scholar
  7. Tosini  F, Visca  P, Luzzi  I, Dionisi  AM, Pezzella  C, Petrucca  A, Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype Typhimurium. Antimicrob Agents Chemother. 1998;42:3053–8.PubMedGoogle Scholar
  8. Hall  RM, Collis  CM. Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol Microbiol. 1995;15:593–600. DOIPubMedGoogle Scholar
  9. Liebert  CA, Hall  RM, Summers  AO. Transposon Tn21, a flagship of the floating genome. Microbiol Mol Biol Rev. 1999;63:507–22.PubMedGoogle Scholar
  10. Colonna  B, Bernardini  M, Micheli  G, Maimone  F, Nicoletti  M, Casalino  M. The Salmonella wien virulence plasmid pZM3 carries Tn1935, a multiresistance transposon containing a composite IS1936-kanamycin resistance element. Plasmid. 1988;20:221–31. DOIPubMedGoogle Scholar
  11. Maimone  F, Colonna  B, Bazzicalupo  P, Oliva  B, Nicoletti  M, Casalino  MA. Plasmids and transposable elements in Salmonella wien. J Bacteriol. 1979;139:369–75.PubMedGoogle Scholar
  12. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disc susceptibility tests. M2A2. Villanova, Pa: The Committee; 1992.
  13. Kado  CI, Liu  S. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol. 1981;145:1365–73.PubMedGoogle Scholar

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