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Volume 8, Number 8—August 2002

Research

Genetic Characterization of Hantaviruses Transmitted by the Korean Field Mouse (Apodemus peninsulae), Far East Russia

Kumari Lokugamage*, Hiroaki Kariwa*Comments to Author , Daisuke Hayasaka*, Bai Zhong Cui*, Takuya Iwasaki†, Nandadeva Lokugamage*, Leonid I. Ivanov‡, Vladimir I. Volkov‡, Vladimir A. Demenev§, Raisa Slonova¶, Galina Kompanets¶, Tatyana Kushnaryova¶, Takeshi Kurata†, Kenji Maeda*, Koichi Araki*, Tetsuya Mizutani*, Kumiko Yoshimatsu#, Jiro Arikawa#, and Ikuo Takashima*
Author affiliations: *Hokkaido University, Sapporo, Japan; †National Institute of Infectious Diseases, Tokyo, Japan; ‡Plague Control Station, Khabarovsk, Russia; §Far Eastern Medical Association, Khabarovsk, Russia; ¶Russian Academy of Medical Sciences, Vladivostok, Russia; #Hokkaido University School of Medicine, Sapporo, Japan;

Main Article

Table 2

Hantavirus sequences used in this studya

Virus type Strain Source Country
 Accession nos.
 References
Region Location M S
HTNV
SL/AP61/1999 Apodemus peninsulae Far East Russia Solovey AB071185 AB071183 This report
SL/AP63/1999 A.peninsulae Far East Russia Solovey AB071186 AB071184 This report
PRI/H1/2000 Human Primorye Cavalerovo AB071187 —b This report
PRI/H2/2000 Human Primorye Cavalerovo AB071188 — This report
AMR/680 A.peninsulae Far East Russia Khabarvosk AF332571 — 11
AMR/1166 A.peninsulae Far East Russia Khabarvosk AF332569 — 11
AMR/1169 A.peninsulae Far East Russia Khabarvosk AF332570 — 11
AMR/4234 Human Far East Russia Amursk AF172422 — 10
AMR/4309 Human Far East Russia Amursk AF172423 — 10
AMR/4313 Human Far East Russia Korphovsky AF172424 — 10
H8205 Human China — AB030232 — —
HTNV261 — China Heilongjiang — AF252259 —
Z10 Human China Zhejiang AB027076 AB027108 12
Chen4 Human China Anhui — AB027101 12
Maaji1 A. agrarius Korea — — AF321094 Lee PW c
Maaji-2 Human Korea — — AF321095 Lee PW c
HTN 76-118 A. agrarius South Korea — M14627 M14626 13,14
Q32 — China Guizhou — AB027097 12
HV114 A. agrarius China Hubei L08753 AB027110 12,15
A9 A. agrarius China Jiangsu AF035831 — 16
Hojo Human South Korea — D00376 — 17
FE/7866 Human Far East Russia Razdolnoye AF172439 — 10
NC167 Niviventer confucianus China Anhui AB027115 AB027523 12
H3 Human China Hubei — — 18
H5 Human China Heilongjiang — — 18
A3 A. agrarius. China Zhejiang AB027055 — 12
B78 Human China Shandong AB027056 AB027093 12
Q36 A. agrarius China Guizhou AB027057 AB027094 12
Q7 A. agrarius China Guizhou AB02058 AB027095 12
Q20 A. agrarius China Guizhou AB027059 AB027096 12
Niongxia-A A. agrarius China Niongxia AB027060 — 12
Q10 A. agrarius China Guizhou AB027062 AB027098 12
A16 A. agrarius China Sanxi AB027063 AB027099 12
Q37 A. agrarius China Guizhou AB027064 AB027100 12
Q33 A. agrarius China Guizhou AB027065 AB027102 12
Bao9 A. agrarius China Heilongjiang AB027066 AB027103 12
Jiang13 A. agrarius China Heilongjiang AB027067 AB027104 12
Bao14 A. agrarius China Heilongjiang AB027068 AB027105 12
Bao10 A. agrarius China Heilongjiang AB027069 AB027106 12
Lee Human South Korea — D00377 — 17
62HTNV — — — AB027070 — 12
6B — — — AB027071 — 12
Vaccine — — — AB027072 — 12
H2 — North Korea — AB027073 AB027107 12
HN26-L A. agrarius China Hainan AB027074 — 12
Luyao Human China Shandong — AB027109 12
B659 Human China Shandong S72339 — 18
Hu Human China Hubei AB027077 AB027111 12
Q83 — — Guizhou AB027078 — 12
B256 — — — AB027079 AB027112 12
Thailand Bandicota indica Thailand — L08756 — —
Topografov Lemmus sibericus Far East Russia Siberia AJ011647 — 9
SEOV
L99 Rattus losea China Jiangxi AF035833 AF288299 —
SR11 R. norvegicus Japan Sapporo M34882 M34881 19
Gou3 R. rattus China Zhejiang AB027521 AB027522 12
NM39 R. norvegicus China Neimeng AB027080 — 12
HB55 Human China Henan AF035832 — 17
Wan Human China Jiangsu AB027081 — 12
J12 Human China Jieling AB027082 — 12
Henan94 R. norvegicus China Henan AB027083 — 12
Shanxi — — — AB027084 — 12
HN71-L R. norvegicus China Hainan AB027085 — 12
Guang199 — — — AB027086 — 12
Beijing-Rn R. norvegicus China Beijing AB027087 — 12
c3 Human China Hebei AB027088 — 12
Hebei4 Cricetulus barabensis China Hebei AB027090 — 12
SD227 — China Shangdong AB027091 — 12
SD10 R. norvegicus China Shangdong AB027092 — 12
Hbei1 Human China Hubei S72343 — 17
Seoul R. norvegicus South Korea — S47716 — 20
Tchoupitoulas R. norvegicus North America — U00473 — 21
B-1 R. norvegicus Japan — X53861 — 22
Girard Point R. norvegicus North America — U00464 — —
DOBV
DOB/SLOV A. flavicollis Slovenia — L33685 L41916 23
DOB/SAA A. agrarius Estonia — AJ009774 AJ009773 4
SNV SNV Peromyscus maniculatus North America — L25783 L25784 24
PUUV PUU/Sot Clethrionomys glareolus Finland — X61034 — 25
Kamiiso C. rufocanus Japan Kamiiso AB011631 — 8
KHAB Khabarovsk Microtis fortis Far East Russia Khabarvosk AJ011648 — 9

aAbbreviations used: HTNV and HTN, Haantan virus; SL, Solovey; PRI, Primorye; AMR, Amur; SEOV, Seoul virus; DOB and DOBV, Dobrava-Belgrade virus; SLOV, Slovenia; SAA, Saarema; SNV, Sin Nombre virus; PUUV, Puumala virus; and KHAB, Khabarovsk virus.
b —, not reported/not used in this study.
cPers. comm.

Main Article

References
  1. Tang  YW, Xu  ZY, Zhu  ZY, Tsai  TF. Isolation of haemorrhagic fever with renal syndrome virus from Suncus murinus, an insectivore. Lancet. 1985;1:513–4. DOIPubMedGoogle Scholar
  2. Plyusnin  A, Vapalahti  O, Vaheri  A. Hantaviruses: genome structure, expression and evolution. J Gen Virol. 1996;77:2677–87. DOIPubMedGoogle Scholar
  3. Clement  J, Heyman  P, McKenna  P, Colson  P, Avsic-Zupanc  T. The hantaviruses in Europe: from the bedside to the bench. Emerg Infect Dis. 1997;3:205–11.PubMedGoogle Scholar
  4. Nemirov  K, Vapalahti  O, Lundkvist  A, Vasilenko  V, Golovljova  I, Plyusnina  A, Isolation and characterization of Dobrava hantavirus in the striped field mouse (Apodemus agrarius) in Estonia. J Gen Virol. 1999;80:371–9.PubMedGoogle Scholar
  5. Scharninhausen  JJ, Meyer  H, Pfeffer  M, Davis  DS, Honeycutt  RL. Genetic evidence of Dobrava virus in Apodemus agrarius in Hungary. Emerg Infect Dis. 1999;5:468–70.PubMedGoogle Scholar
  6. Peters  CJ, Gary  LS, Levy  H. Spectrum of hantavirus infection: Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Annu Rev Med. 1999;50:531–45. DOIPubMedGoogle Scholar
  7. Horling  J, Chizhikov  V, Lundkvist  A. Khabarovsk virus: a phylogenetically and serologically distinct hantavirus isolated from Microtus fortis trapped in Far East Russia. J Gen Virol. 1996;77:687–94. DOIPubMedGoogle Scholar
  8. Kariwa  H, Yoshimatsu  K, Sawabe  J, Yokota  E, Arikawa  J, Takashima  I, Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia. Virus Res. 1999;59:219–28. DOIPubMedGoogle Scholar
  9. Vapalahti  O, Lundkvist  A, Fedorov  V, Conroy  CJ, Hirvonen  S, Plyusnina  A, Isolation and characterization of hantavirus from Lemmus sibiricus: evidence for host switch during hantavirus evolution. J Virol. 1999;73:5586–92.PubMedGoogle Scholar
  10. Yashina  LN, Pastrshev  NP, Ivanov  LI, Slonova  RA, Mishin  VP, Kompanez  GG, Genetic diversities of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. Virus Res. 2000;70:31–44. DOIPubMedGoogle Scholar
  11. Yashina  L, Mishin  V, Zdanovskaya  N, Schmaljohn  C, Ivanov  L. A newly discovered variant of a Hantavirus in Apodemus peninsulae, Far Eastern Russia. Emerg Infect Dis. 2001;7:912.PubMedGoogle Scholar
  12. Wang  H, Yoshimatsu  K, Ebihara  H, Ogino  M, Araki  K, Kariwa  H, Genetic diversity of hantaviruses isolated in China and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology. 2000;278:332–45. DOIPubMedGoogle Scholar
  13. Schmaljohn  CS, Jening  GB, Hay  J, Dalrymple  JM. Coding strategy of the S genome segment of Hantaan virus. Virology. 1986;155:633–43. DOIPubMedGoogle Scholar
  14. Schmaljohn  CS, Schmaljohn  AL, Dalrymple  JM. Hantaan virus mRNA: coding strategy, nucleotide sequence, and gene order. Virology. 1987;157:31–9. DOIPubMedGoogle Scholar
  15. Xiao  SY, Liang  M, Schmaljohn  CS. Molecular and antigenic characterization of HV114, a hantavirus isolated from a patient with haemorrhagic fever with renal syndrome in China. J Gen Virol. 1993;74:1657–9. DOIPubMedGoogle Scholar
  16. Shi  XH, Liang  MF, Hang  CS, Gan  S, McCaughey  C, Eliott  RM. Nucleotide sequence and phylogenetic analysis of the medium (M) genomic RNA segments of three hantaviruses isolated in China. Virus Res. 1998;56:69–76. DOIPubMedGoogle Scholar
  17. Schmaljohn  CS, Arikawa  J, Hasty  SE, Rasmussen  L, Lee  HW, Lee  PW, Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients. J Gen Virol. 1988;69:1949–55. DOIPubMedGoogle Scholar
  18. Liang  M, Li  D, Xiao  SY, Hang  C, Rossi  CA, Schmaljohn  CS. Antigenic and molecular characterization of hantavirus isolates from China. Virus Res. 1994;31:219–33. DOIPubMedGoogle Scholar
  19. Arikawa  J, La Penotiere  HF, Iacono-Connors  L, Wang  MG, Schmaljohn  CS. Coding properties of the S and the M genome segments of Sapporo rat virus: comparison to other causative agents of hemorrhagic fever with renal syndrome. Virology. 1990;176:114–25. DOIPubMedGoogle Scholar
  20. Antic  D, Lim  BU, Kang  CY. Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparison with other hantaviruses reveal the evolutionary pathway. Virus Res. 1991;19:47–58. DOIPubMedGoogle Scholar
  21. Xiao  SY, Leduc  JW, Chu  YK, Schmaljohn  CS. Phylogenetic analysis of virus isolates in the genus Hantavirus, family Bunyaviridae. Virology. 1994;198:205–17. DOIPubMedGoogle Scholar
  22. Isegawa  Y, Fujiwara  Y, Ohshima  A, Fukunaga  R, Murakami  H, Yamanishi  K, Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1. Nucleic Acids Res. 1990;18:4936. DOIPubMedGoogle Scholar
  23. Avsic-Zupanc  T, Toney  A, Anderson  K, Chu  YK, Schmaljohn  C. Genetic and antigenic properties of Dobrava virus; a unique member of the Hantavirus genus, family Bunyaviridae. J Gen Virol. 1995;76:2801–8. DOIPubMedGoogle Scholar
  24. Chizhikov  VE, Spiropoulou  CF, Morzunov  SP, Monroe  MC, Peters  CJ, Nichol  ST. Complete genetic characterization and analysis and isolation of Sin Nombre virus. J Virol. 1995;69:8132–6.PubMedGoogle Scholar
  25. Vapalahti  O, Kallio-Kokko  H, Salonen  EM, Brummer-Korvenkontio  M, Vaheri  A. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segment: evidence for strain variation in Hantavirus and expression of the nucleocapsid protein. J Gen Virol. 1992;73:829–38. DOIPubMedGoogle Scholar
  26. Lee  HW, Lee  PW, Tamura  M, Tamura  T, Okuno  Y. Etiological relation between Korean hemorrhagic fever and epidemic hemorrhagic fever in Japan. Biken J. 1979;22:41–5.PubMedGoogle Scholar
  27. Nichol  ST, Spiropoulou  CF, Morzunov  S, Rollin  PE, Ksiazek  TG, Feldmann  H, Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science. 1993;262:914–7. DOIPubMedGoogle Scholar
  28. Childs  JE, Ksiazek  TG, Spiropoulou  CF, Krebs  JW, Morzunov  S, Maupin  GO, Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis. 1994;169:1271–80.PubMedGoogle Scholar
  29. Rollin  PE, Ksiazek  TG, Elliot  LH, Ravkov  EV, Martin  ML, Morzunov  S, Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida. J Med Virol. 1995;46:35–9. DOIPubMedGoogle Scholar
  30. Ksiazek  TG, Nichol  ST, Mills  JN, Groves  MG, Wozniak  A, McAdams  S, Isolation, genetic diversity, and geographic distribution of Bayou virus (Bunyaviridae; hantavirus). Am J Trop Med Hyg. 1997;57:445–8.PubMedGoogle Scholar
  31. Schmaljohn  C, Hjelle  B. Hantaviruses:a global disease problem. Emerg Infect Dis. 1997;3:95–104.PubMedGoogle Scholar
  32. Mustonen  J, Helin  H, Pietila  K, Brummer-Korvenkontio  M, Hedman  K, Vaheri  A, Renal biopsy findings and clinicopathologic correlations in nephropathia epidemica. Clin Nephrol. 1994;41:121–6.PubMedGoogle Scholar
  33. Grcevska  L, Polenakovic  M, Oncervski  A, Zografski  D, Gligic  A. Different pathohistological presentations of acute renal involvement in Hantaan virus infection: report of two cases. Clin Nephrol. 1990;34:197–201.PubMedGoogle Scholar
  34. Bren  AF, Pavlovcic  SK, Koselj  M, Kovac  J, Kandus  A, Kveder  R. Acute renal failure due to hemorrhagic fever with renal syndrome. Ren Fail. 1996;18:635–8. DOIPubMedGoogle Scholar
  35. Polenakovic  M, Grcevska  L, Gerasimovska-Tanevska  V, Oncevski  A, Dzikova  S, Cakalaroski  K, Hantaan virus infection with acute renal failure. Artif Organs. 1995;19:808–13. DOIPubMedGoogle Scholar

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