Table 2

Tick-Borne Encephalitis with Hemorrhagic Syndrome, Novosibirsk Region, Russia, 1999

Vladimir A. Ternovoi*, Gennady P. Kurzhukov†, Yuri V. Sokolov‡, Gennady Y. Ivanov‡, Vladimir A. Ivanisenko*, Alexander V. Loktev§, Robert W. Ryder¶, Sergey V. Netesov*, and Valery B. Loktev*

Author affiliations: *State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region, Russi; †Novosibirsk State Medical Academy, Novosibirsk, Russia; ‡First Municipal Clinical Infectious Hospital of Novosibirsk, Novosibirsk, Russia; §Stanford University, Palo Alto, California, USA; ¶University of North Carolina, Chapel Hill, North Carolina, USA

Main Article

Mutations in the amino acid sequence of protein E of hemorrhagic variants of TBEV^a

Amino acid, position	TBEV, 205	Mutation in hemorrhagic TBEV	Variants of hemorrhagic TBEV	Mutations in other flaviviruses^b
121	Cys	Gly	Koltsovo 31
128	Thr	Ala	Koltsovo 19	Val,^c Ser,^d Ala,^e Ile^f
129	Gly	Arg	Koltsovo 31	Leu^d
138	Val	Ala	Koltsovo 19	Thr,^c,g Gln,^d Lys,^e,f,h–k Glu^l,m
141	Val	Asp	Koltsovo 31	Val,^c,d,g Glu,^{e,f, h,i} Ser,^j Thr^k,l,m
170	Glu	Gly	Koltsovo 29	Gly,^d Pro,^e,f,h–j,m Ser,^k,l
171	Arg	Lys	Koltsovo 1	Lys,^c,g Ser,^d,f,h,i,m Ala,^e Thr,^j,k Ile^l
189	Ala	Ser	Koltsovo 23	Thr,^g Gln,^d Arg,^e,f,h–1 Gly^m
223	Leu	Trp	Koltsovo 23
224	Ala	His	Koltsovo 23	Ser,^g Thr,^d Leu,^e Asn,^h,i Pro^j–m
244	Phe	Cys	Koltsovo 30
245	Gly	Val	Koltsovo 29	Glu,^d–f,h,i Lys^j–m
249	Ala	Arg	Koltsovo 30

^aTBEV, tick-borne encephalitis virus.
^bAlignment of protein E sequences was carried out with data from the Protein Families database (available from: URL: http://www.sanger.ac.uk/Software/Pfam/).
^cPowassan virus, strain LB (Q04538).
^dYellow fever virus, strain 17D (P03314).
^eMurray valley encephalitis virus (P05769).
^fJapanese encephalitis virus, strain CH2195 (O09754).
^gKyasanur forest disease virus (SWISS-PROT Q82951).
^hKunjin virus, strain MRM61C (P14335).
ⁱSt. Louis encephalitis virus, strain MS1-7 (Q88788).
^jDengue virus type 1 (O10246).
^kDengue virus type 3 (P27915).
^lDengue virus type 2, strain 16681 (O09234).
^mDengue virus type 4 (Q88668).

Main Article

Page created: December 22, 2010

Page updated: December 22, 2010

Page reviewed: December 22, 2010

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Volume 9, Number 6—June 2003

Dispatch

Tick-Borne Encephalitis with Hemorrhagic Syndrome, Novosibirsk Region, Russia, 1999

Table 2