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Volume 9, Number 6—June 2003

Dispatch

Tick-Borne Encephalitis with Hemorrhagic Syndrome, Novosibirsk Region, Russia, 1999

Vladimir A. Ternovoi*, Gennady P. Kurzhukov†, Yuri V. Sokolov‡, Gennady Y. Ivanov‡, Vladimir A. Ivanisenko*, Alexander V. Loktev§, Robert W. Ryder¶, Sergey V. Netesov*, and Valery B. Loktev*Comments to Author 
Author affiliations: *State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region, Russi; †Novosibirsk State Medical Academy, Novosibirsk, Russia; ‡First Municipal Clinical Infectious Hospital of Novosibirsk, Novosibirsk, Russia; §Stanford University, Palo Alto, California, USA; ¶University of North Carolina, Chapel Hill, North Carolina, USA

Main Article

Table 2

Mutations in the amino acid sequence of protein E of hemorrhagic variants of TBEVa

Amino
acid, position TBEV,
205 Mutation in
hemorrhagic TBEV Variants of hemorrhagic TBEV Mutations in other flavivirusesb
121
 Cys
 Gly
 Koltsovo 31
128
 Thr
 Ala
 Koltsovo 19
 Val,c Ser,d Ala,e Ilef
129
 Gly
 Arg
 Koltsovo 31
 Leud
138
 Val
 Ala
 Koltsovo 19
 Thr,c,g Gln,d Lys,e,f,h–k Glul,m
141
 Val
 Asp
 Koltsovo 31
 Val,c,d,g Glu,e,f, h,i Ser,j Thrk,l,m
170
 Glu
 Gly
 Koltsovo 29
 Gly,d Pro,e,f,h–j,m Ser,k,l
171
 Arg
 Lys
 Koltsovo 1
 Lys,c,g Ser,d,f,h,i,m Ala,e Thr,j,k Ilel
189
 Ala
 Ser
 Koltsovo 23
 Thr,g Gln,d Arg,e,f,h–1 Glym
223
 Leu
 Trp
 Koltsovo 23
224
 Ala
 His
 Koltsovo 23
 Ser,g Thr,d Leu,e Asn,h,i Proj–m
244
 Phe
 Cys
 Koltsovo 30
245
 Gly
 Val
 Koltsovo 29
 Glu,d–f,h,i Lysj–m
249 Ala Arg Koltsovo 30

aTBEV, tick-borne encephalitis virus.
bAlignment of protein E sequences was carried out with data from the Protein Families database (available from: URL: http://www.sanger.ac.uk/Software/Pfam/).
cPowassan virus, strain LB (Q04538).
dYellow fever virus, strain 17D (P03314).
eMurray valley encephalitis virus (P05769).
fJapanese encephalitis virus, strain CH2195 (O09754).
gKyasanur forest disease virus (SWISS-PROT Q82951).
hKunjin virus, strain MRM61C (P14335).
iSt. Louis encephalitis virus, strain MS1-7 (Q88788).
jDengue virus type 1 (O10246).
kDengue virus type 3 (P27915).
lDengue virus type 2, strain 16681 (O09234).
mDengue virus type 4 (Q88668).

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Page created: December 22, 2010
Page updated: December 22, 2010
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