Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 1, Number 4—October 1995
Dispatch

Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice

Jerry M. Rice
Author affiliation: Laboratory of Comparative Carcinogenesis, National
 Cancer Institute, Frederick, Maryland, USA

Main Article

Table

Increasing prevalence of hepatitis and hepatocellular neoplasia in control male A/JCr mice at the National Cancer Institute's Frederick Cancer Research and Development Center, 1989-1992a

Date Killed Number of mice Age, in weeks Mice with hepatitis (%) Mice with liver tumors (%)
Jan-Mar 1989 48 47±3 0 0
May-Jul 1989 47 70±360 0 1 (2)
Jan-Apr 1992 6 36±34 2 (33) 0
Jul 1992 16 54 16 (100) 1 (6)
Aug-Oct 1992 64±3 5 (83) 3 (50)
Dec 1992 77 12 (100) 11 (92)

Adapted from ref. 4.

Main Article

References
  1. Parsonnet  J, Friedman  GD, Vandersteen  DP, Chang  Y, Vogelman  JH, Orentreich  N, Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325:1127–31.PubMedGoogle Scholar
  2. Wotherspoon  AC, Doglioni  C, Diss  TC, Pan  L, Moschini  A, de Boni  M, Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–7. DOIPubMedGoogle Scholar
  3. Bayerdörffer  E, Neubauer  A, Rudolph  B, Thiede  C, Lehn  N, Eidt  S, Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. Lancet. 1995;345:1591–4. DOIPubMedGoogle Scholar
  4. Ward  JM, Fox  JG, Anver  MR, Haines  DC, George  CV, Collins  MJ Jr, Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J Natl Cancer Inst. 1994;86:1222–7. DOIPubMedGoogle Scholar
  5. Ward  JM, Anver  MR, Haines  DC, Benveniste  RE. Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol. 1994;145:959–68.PubMedGoogle Scholar
  6. Garvey  W, Fathi  A, Bigelow  F. Modified Steiner for the demonstration of spirochetes. J Histotechnol. 1985;8:15–7.
  7. Fox  JG, Dewhirst  FE, Tully  JG, Paster  BJ, Yan  L, Taylor  NS, Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J Clin Microbiol. 1994;32:1238–45.PubMedGoogle Scholar
  8. Battles  JK, Williamson  JC, Pike  KM, Gorelick  PL, Ward  JM, Gonda  MA. Diagnostic assay for Helicobacter hepaticus based on nucleotide sequence of its 16S rRNA gene. 1995;33:1344-7.
  9. Kita  E, Oku  D, Hamuro  A, Nishikawa  F, Emoto  M, Yagyu  Y, Hepatotoxic activity of Campylobacter jejuni. J Med Microbiol. 1990;33:171–82. DOIPubMedGoogle Scholar
  10. Taylor  NS, Fox  JG, Yan  L. In-vitro hepatotoxic factor in Helicobacter hepaticus, H. pylori and other Helicobacter species. J Med Microbiol. 1995;42:48–52. DOIPubMedGoogle Scholar
  11. Ohshima  H, Bartsch  H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res. 1994;305:253–64. DOIPubMedGoogle Scholar
  12. Foltz  CJ, Fox  JG, Yan  L, Shames  B. Evaluation of antibiotic therapies for eradication of Helicobacter hepaticus. Antimicrob Agents Chemother. 1995;39:1292–4.PubMedGoogle Scholar
  13. Handt  LK, Fox  JG, Dewhirst  FE, Fraser  GJ, Paster  BJ, Yan  LL, Helicobacter pylori isolated from the domestic cat: public health implications. Infect Immun. 1994;62:2367–74.PubMedGoogle Scholar

Main Article

Page created: December 20, 2010
Page updated: December 20, 2010
Page reviewed: December 20, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external