Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 10, Number 2—February 2004
THEME ISSUE
2004 SARS Edition
Laboratory Study

Interferon-β 1a and SARS Coronavirus Replication

Lisa E. Hensley*, Elizabeth A. Fritz*, Peter B. Jahrling*Comments to Author , Christopher Karp†, John W. Huggins*, and Thomas W. Geisbert*
Author affiliations: *U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA; †Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

Main Article

Figure 1

Interferon (IFN)-β 1a inhibition of SARS-CoV replication in Vero E-6 cells. Top panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 24 h before infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Bottom panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 1 h after infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Three concentrations of IFN-β 1a were employed for both studies: 5,000 IU/m

Figure 1. Interferon (IFN)-β 1a inhibition of SARS-CoV replication in Vero E-6 cells. Top panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 24 h before infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Bottom panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 1 h after infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Three concentrations of IFN-β 1a were employed for both studies: 5,000 IU/mL (-□-), 50,000 IU/mL (-■-), 500,000 IU/mL (-■-) Samples of overlying media were collected at 24, 48, and 72 h postinfection and analyzed by plaque assay on Vero E-6 cells.

Main Article

Page created: January 25, 2011
Page updated: January 25, 2011
Page reviewed: January 25, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external