Volume 13, Number 12—December 2007
Research
Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)
John Pasick*
, Yohannes Berhane*, Carissa Embury-Hyatt*, John Copps*, Helen Kehler*, Katherine Handel*, Shawn Babiuk*, Kathleen Hooper-McGrevy*, Yan Li†, Quynh Mai Le‡, and Song Lien Phuong§
, Yohannes Berhane*, Carissa Embury-Hyatt*, John Copps*, Helen Kehler*, Katherine Handel*, Shawn Babiuk*, Kathleen Hooper-McGrevy*, Yan Li†, Quynh Mai Le‡, and Song Lien Phuong§
Table 2
Distribution of influenza virus antigen in tissues of naïve juvenile Canada geese tissues after challenge with influenza virus (H5N1)
| Tissue | Animal 861S/36R dpi 3* | Animal 855S/30R dpi 4* | Animal 851S/26R dpi 5* | Animal 854S/29R dpi 5* | Animal 860S/35R dpi 5* | IHC-positive cell types |
|---|---|---|---|---|---|---|
| Trachea | + | + | – | – | – | Vascular endothelium |
| Lung | ++ | ++ | – | + | – | Vascular endothelium, mononuclear cells |
| Esophagus | ++ | ++ | + | + | – | Epithelium, Vascular smooth muscle, Smooth muscle of muscularis externa, Mucous glands |
| Proventriculus | + | + | – | ++ | – | Epithelium (columnar, glandular), muscularis mucosa, vascular smooth muscle, parasympathetic ganglia |
| Ventriculus | ++ | ++ | – | ++ | – | Epithelium |
| Gut | ++ | +++ | – | ++ | + | Parasympathetic ganglia, mucosal smooth muscle, vascular endothelium |
| Cecal tonsil | ++ | ++ | + | ++ | – | Parasympathetic ganglia |
| Pancreas | ++ | +++ | ++ | ++ | + | Exocrine acinar cells |
| Liver | – | – | – | + | – | Hepatocytes |
| Spleen | ++ | – | + | – | – | Vascular smooth muscle, mononuclear cells |
| Kidney | + | – | – | – | – | Tubular epithelium |
| Muscle | + | + | – | – | – | Vascular smooth muscle |
| Heart | ++ | ++ | ++ | + | + | Myocytes |
| Brain | ++ | +++ | +++ | +++ | +++ | Neurons, glial cells, ependymal cells, choroid plexus epithelium |
| Spinal cord | + | ++ | ++ | ++ | ++ | Ependymal cells, neurons, glial cells, leptomeninges |
| Sciatic nerve | + | – | – | – | – | Vascular endothelium |
| Brachial nerve | – | – | – | – | – | None |
*Numbers of immunohistochemically positive cells: +, few; ++, moderate; +++, numerous; –, virus antigen negative; dpi, days postinfection.
Page created: July 06, 2010
Page updated: July 06, 2010
Page reviewed: July 06, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.