Volume 13, Number 7—July 2007
Research
Ongoing Genome Reduction in Mycobacterium ulcerans
Simona Rondini*1, Michael Käser*1, Timothy P. Stinear†2, Michel Tessier‡, Cyrill Mangold‡, Gregor Dernick‡, Martin Naegeli*, Françoise Portaels§, Ulrich Certa‡, and Gerd Pluschke*
Table
Features of the 15 distinct deletions identified in Mycobacterium ulcerans isolates*
| RD | Deletion no. | Plasmid no. | Origin | Size of deletion, kb | No. CDSs and pseudogenes |
|---|---|---|---|---|---|
| 1 | 1 | p8 | SU/FG | 11.1 | 14 |
| 2 | 2 | p34 | SU/FG | 6.6–6.8 | 4 |
| 3 | 3A | p58 | AU1/AU2 | 3.5 | 5 |
| 3B | p58 | SU/FG | 3.8 | 6 | |
| 4 | 4 | p60, p61 | SU/FG | 1.8–2.4 | 2 |
| 5 | 5 | p88, p153, p360 | ME1/ME2 | 27.1–27.4 | 23 |
| 6 | 6 | p92 | JP/CH/ME1/ME2 | 19.7 | 24 |
| 7 | 7 | p100 | SU/FG | 15.3 | 13 |
| 8 | 8 | p124, p291 | ME1/ME2 | 52.8–53.1 | 50 |
| 9 | 9A | p144 | JP/CH | 18.1 | 15 |
| 9B | p144 | SU/FG | 25.4 | 20 | |
| 10 | 10 | p170 | ME1/ME2 | 8.2–8.7 | 10 |
| 11 | 11 | p305 | JP/CH | 4.6 | 7 |
| 12 | 12A | p315 | JP/CH | 53.1 | 50 |
| 12B | p315 | SU/FG | 35.4–35.5 | 32 |
*RD, region of difference; CDSs, coding sequences; SU, Suriname; FG, French Guiana; AU, Australia; ME, Mexico; JP, Japan; CH, China.
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