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Volume 14, Number 2—February 2008
Research

Genetic Determinants of Virulence in Pathogenic Lineage 2 West Nile Virus Strains

Elizabeth M. Botha*, Wanda Markotter*, Mariaan Wolfaardt*, Janusz T. Paweska†, Robert Swanepoel†, Gustavio Palacios‡, Louis H. Nel*, and Marietjie Venter*Comments to Author 
Author affiliations: *University of Pretoria, Pretoria, South Africa; †National Institute for Communicable Diseases, Sandringham, South Africa; ‡Columbia University, New York, New York, USA;

Main Article

Table 2

Percentage of amino acid and nucleotide differences when comparing the entire genome of selected West Nile virus strains*

Strain SA381/00 H442 SPU116/89 SA93/01 B956D117B3 B956 ANMg798 NY-385–99 NY-385–99 Clone
TYP-9376 NY-385–99 Clone
9317B TM171–03 MRM61C
SA381/00 2.4 3.6 3.7 3.1 2.9 15.8 20.6 20.6 20.6 20.6 20.5
H442 0.7 2.7 3.0 1.8 1.6 15.6 20.5 20.6 20.6 20.5 20.6
SPU116/89 0.9 0.7 1.3 2.0 1.9 16.0 20.8 20.9 20.9 20.8 20.7
SA93/01 0.8 0.7 0.6 2.3 2.2 15.7 20.8 20.9 20.9 20.8 20.6
B956D117B3 1.0 0.8 1.0 0.9 0.3 15.7 20.7 20.7 20.7 20.7 20.6
B956 0.7 0.6 0.7 0.7 0.7 15.8 20.7 20.7 20.7 20.7 20.6
AnMg798 3.4 3.3 3.5 3.4 3.5 3.4 21.5 21.5 21.5 21.4 21.2
NY-385–99 6.0 5.9 6.1 6.1 6.1 6 6.6 0.1 0.1 0.4 11.7
NY-385–99
Clone TYP-9376 6.1 6.0 6.2 6.2 6.2 6.1 6.7 0.1 0 0.5 11.8
NY-385–99
Clone 9317B 6.1 6.0 6.2 6.2 6.2 6.1 6.7 0.1 0.0 0.5 11.8
TM171–03 6.0 5.9 6.1 6.1 6.1 6 6.7 0.1 0.2 0.2 11.8
MRM61C 6.5 6.5 6.7 6.6 6.6 6.5 7.1 2.4 2.4 2.4 2.4

*The lower left matrix corresponds to amino acid sequences, and the upper right matrix corresponds to nucleotide sequences.

Main Article

Page created: July 07, 2010
Page updated: July 07, 2010
Page reviewed: July 07, 2010
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