Volume 14, Number 4—April 2008
Research
Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt1
, Ruth M. Pfeiffer*, Bryan Dolan*, Victor C.W. Tsang†, John Noh†, Nabiel N.H. Mikhail‡, Mohamed Abdel-Hamid§¶, Mohamed Hashem§¶, Denise Whitby#, G. Thomas Strickland¶, and James J. Goedert*
Table 3
Adjusted OR of association of HHV-8 seropositivity with demographic and clinical variables among adults, Egypt*
| Characteristic | Men |
Women |
|||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | ||
| Age group, y† | 0.002 | ||||||
| 15–24 | Ref | – | – | Ref | – | – | |
| 25–34 | 1.6 | 1.2–2.2 | – | 0.8 | 0.4–1.6 | 0.53 | |
| 35–44 | 2.6 | 1.4–4.9 | – | 1.5 | 0.8–2.9 | 0.15 | |
| >45 |
4.3 |
1.7–11.0 |
– |
3.1 |
1.5–6.4 |
<0.001 |
|
| Dental treatments‡ | 0.04 | ||||||
| No | Ref | – | – | – | – | – | |
| Yes |
2.3 |
1.1–4.9 |
– |
– |
– |
– |
|
| HCV serostatus‡ | – | 0.007 | |||||
| Negative | – | – | – | Ref | – | – | |
| Positive |
– |
– |
– |
3.3 |
1.4–7.9 |
– |
|
| Schistosomiasis§ | 0.47 | 0.07 | |||||
| Negative | Ref | – | – | Ref | – | – | |
| Positive | 2.3 | 0.3–16.1 | – | 1.5 | 1.0–2.5 | – | |
*OR, odds ratio; HHV-8, human herpesvirus 8; CI, confidence interval; Ref, referrent; HCV, hepatitis C virus.
†p value is for age group fitted with trend among men; p values for heterogeneity for categories given for women (see Statistical Methods).
‡Missing values in sex-specific analyses mean the variable was not significant and was excluded from final multivariable model.
§Schistosomiasis seropositivity was included in models even when not significant because we hypothesized a priori that it was associated with HHV-8 seropositivity (see online Appendix, available from www.cdc.gov/EID/content/14/4/586-app.htm).
1Results were presented, in part, at the 9th International Workshop on Kaposi’s Sarcoma–associated Herpesvirus (KSHV) and Related Agents, Cape Cod, Massachusetts, USA, July 12–15, 2006.