Volume 14, Number 9—September 2008
Synopsis
Questions on Mediterranean Spotted Fever a Century after Its Discovery
Clarisse Rovery, Philippe Brouqui, and Didier Raoult
Table 1
Historical reports of MSF*
| Year | Discovery | Authors† |
|---|---|---|
| 1910 | Description of the “fièvre boutonneuse de Tunisie” (7 cases) | Conor and Bruch |
| 1925 | Description of a cluster of MSF (8 cases) in Marseille, France, during the summer | Olmer |
| 1927 | Description of the inoculation eschar, the tache noire (black spot). Description of the disease associating fever, spots, and eschar as “Marseille fever” | Boinet and Pieri |
| 1930 | Experimental transmission of the disease by the brown dog tick | Durand and Conseil |
| 1932 | Demonstration of the transstadial and transovarian transmission of the agent of MSF in ticks. Demonstration of Rickettsia in infected ticks | Blanc and Caminopetros |
| 1932 | Isolation of the Rickettsia causing MSF in the vagina of infected guinea pigs and in infected ticks; named R. conorii | Brumpt |
| 1982 | First description of cases of malignant MSF | Raoult |
*MSF, Mediterranean spotted fever.
†First or senior authors.
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