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Volume 15, Number 5—May 2009
Letter

Near-Fatal Multiple Organ Dysfunction Syndrome Induced by Plasmodium malariae

Pierre-Néri DescheemaekerComments to Author , Jean-Paul Mira, Fabrice Bruneel, Sandrine Houzé, Michèle Tanguy, Jean-Pierre Gangneux, Erwan Flecher, Christophe Rousseau, Jacques Le Bras, and Yannick Mallédant
Author affiliations: Hôpital Pontchaillou, Université de Rennes 1, Rennes, France (P.-N. Descheemaeker, M. Tanguy, J.-P. Gangneux, E. Flecher, Y. Mallédant); Hôpital Cochin, Port-Royal, Paris, France (J.-P. Mira, C. Rousseau); Centre Hospitalier de Versailles, Versailles, France (F. Bruneel); Hôpital Bichat Claude-Bernard, Paris (S. Houzé, J. Le Bras)

Main Article

Table

Results of genetic screening for single nucleotide polymorphisms known to be associated with sepsis severity in patient with Plasmodium malariae infection, France*

Gene rs Wild type Heterozygous Homozygous
Pathogen detection
TLR2 5743708 X
TLR2 5743704 X
TLR4 4986790 X
TLR5 5744168 X
CD14 2569190 X
MD-2 –1625C/G X
FcγRIIa 1801274 X
MBL2 52 A/D X
MBL2 54 A/B X
MBL2 57 A/C X
MBL2 –550 H/L X
MBL2 –221 X/Y X
MBL2
 +4 P/Q
 X
TLR signaling
IRAK1 1059703 X
TIRAP 8177374 X
IκB 3138053 X
IκB
 2233406
X
Inflammation
Lymphotoxin α 909253 X
TNF α 1800629 X
ACE 17236674 X
MIF 755622 X
IL-6 1800795 X
IL-10
 1800896
 X
Coagulation
PAI-1 1799768 X
Factor V 6025 X

*Except for MD-2 and MBL2, rs is the nomenclature used to describe the variants (initially described by den Dunnen and Antonarakis [4]). TLR, toll-like receptor; MBL2, mannose-binding lectin 2; IRAK-1, interleulin-1 receptor-associated kinase; TIRAP, toll interleukin-1 receptor-associated protein; IκB:, inhibitor of Nf-κB; TNF, tumor necrosis factor; ACE, angiotensin-converting enzyme; MIF, macrophage migration inhibitory factor; IL, interleukin; PAI-1, plaminogen activator inhibitor-1.

Main Article

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Page updated: December 20, 2010
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