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Volume 15, Number 9—September 2009
Research

Predicting Phenotype and Emerging Strains among Chlamydia trachomatis Infections

Deborah DeanComments to Author , William J. Bruno, Raymond Wan, João P. Gomes, Stéphanie Devignot, Tigist Mehari, Henry J.C. de Vries, Servaas A. Morré, Garry Myers, Timothy D. Read, and Brian G. Spratt
Author affiliations: Children’s Hospital Oakland Research Institute, Oakland, California, USA (D. Dean, R. Wan, T. Mehari); University of California, San Francisco, California, USA (D. Dean); University of California, Berkeley, California, USA (D. Dean); Los Alamos National Laboratories, Los Alamos, New Mexico, USA (W.J. Bruno); National Institute of Health, Lisbon, Portugal (J.P. Gomes); Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France (S. Devignot); University of Amsterdam, the Netherlands (H.J.C. de Vries); Vrije Universiteit Medical Center, Amsterdam (S.A. Morré); University of Maryland School of Medicine, Baltimore, Maryland, USA (G. Myers); Emory University, Atlanta, Georgia, USA (T.D. Read); Imperial College, London, UK (B.G. Spratt)

Main Article

Table 3

Allele frequencies by geographic region by locus

Gene locus No. alleles Allele frequency, no. (%)*
 Classification index
p value
Africa
(n = 11) Northern Europe (n = 14) Southern Europe (n = 10) Asia
(n = 13) North America
(n = 33) South America
(n = 6)
glyA
 7
 3 (90.9)
6 (9.1)
 1 (7.1)
3 (42.9)
4 (7.1)
5 (14.3)
6 (28.6)
 3 (60)
6 (40)
 3 (30.8)
6 (7.7)
7 (61.5)
 1 (15.1)
2 (3.0)
3 (54.6)
6 (27.3)
 3 (33.3)
6 (66.7)
 <0.001
mdhC
 4
 3 (90.9)
4 (9.1)
 1 (7.1)
2 (14.3)
3 (64.3)
4 (14.3)
 3 (80)
4 (20)
 3 (100)
 1 (18.2)
3 (72.7)
4 (9.1)
 3 (50.0)
4 (50.0)
 <0.001
pdhA
 7
 1 (9.1)
3 (90.9)
 2 (7.1)
3 (92.9)
 3 (60)
4 (30)
7 (10)
 3 (100)
 3 (94.0)
5 (3.0)
6 (3.0)
 3 (100.0)
 <0.001
yhbG
 8
 2 (9.1)
6 (90.9)
 2 (28.6)
3 (7.1)
6 (42.7)
8 (21.4)
 2 (40)
6 (50)
7 (10)
 1 (7.7)
4 (7.7)
5 (7.7)
6 (76.9)
 2 (21.2)
3 (3.0)
5 (3.0)
6 (57.6)
8 (15.2)
 2 (66.7)
6 (33.3)
 <0.001
pykF
 7
 3 (81.8)
6 (9.1)
7 (8.1)
 1 (12.5)
6 (50)
7 (37.5)
 6 (60)
7 (40)
 3 (92.3)
7 (7.7)
 1 (18.2)
2 (9.1)
4 (3.0)
5 (3.0)
6 (39.4)
7 (27.3)
 6 (33.3)
7 (66.7)
 <0.001
lysS
 8
 4 (15.2)
5 (72.7)
7 (9.1)
 1 (14.3)
4 (78.6)
8 (7.1)
 4 (70)
8 (30)
 4 (7.7)
5 (30.8)
6 (61.5)
 1 (3.0)
3 (3.0)
4 (75.8)
8 (18.2)
 2 (16.7)
4 (66.7)
8 (16.7)
 <0.001
leuS
 11
 2 (9,1)
3 (9.1)
9 (81.8)
 3 (57.1)
6 (21.4)
11(21.4)
 3 (80)
4 (10)
5 (10)
 2 (7.7)
7 (84.6)
10 (7.7)
 1 (3.0)
3 (48.5)
8 (30.3)
9 (3.0)
11 (15.2)
 3 (100.0)
 <0.001
Total no. alleles 52 17 24 17 17 31 13

*Numbers are arranged vertically for each locus to represent the individual alleles (e.g., glyA, alleles are assigned 1, 2, 3, 4, 5, 6 and 7 because there are 7 alleles for this locus). Alleles marked in boldface are specific for a single geographic region. n values indicate number of samples.

Main Article

Page created: December 07, 2010
Page updated: December 07, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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