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Volume 2, Number 3—July 1996
Dispatch

Two Morbilliviruses Implicated in Bottlenose Dolphin Epizootics

Jeffery K. Taubenberger*, Mark Tsai*, Amy E. Krafft*, Jack H. Lichy*, Ann H. Reid*, F. Yvonne Schulman†, and Thomas P. Lipscomb†
Author affiliations: *Division of Molecular Pathology, Department of Cellular Pathology; †Department of Veterinary Pathology, Armed Forces Institute of Pathology,Washington, DC 20306-6000 USA

Main Article

Table 1

Case summary

Date found Stranding by state Dolphin species Morbillivirus sequencea
4 Aug. 1987 New Jersey Tursiops truncatus DMV
5 Aug. 1987 New Jersey T. truncatus DMV
9 Aug. 1987 New Jersey T. truncatus DMV
11 Aug. 1987 New Jersey T. truncatus DMV
23 Aug. 1987 New Jersey T. truncatus DMV + PMV
3 Sep. 1987 New Jersey Stenella coeruloalba DMV
5 Sep. 1987 New Jersey T. truncatus DMV + PMV
6 Sep. 1987 New Jersey T. truncatus PMV
14 Aug. 1987 Virginia T. truncatus PMV
14 Aug. 1987 Virginia T. truncatus DMV + PMV
15 Aug. 1987 Virginia T. truncatus PMV
26 Aug. 1987 Virginia T. truncatus DMV + PMV
29 Aug. 1987 Virginia T. truncatus PMV
29 Aug. 1987 Virginia T. truncatus DMV
4 Sep. 1987 Virginia T. truncatus DMV
5 Oct. 1987 Virginia T. truncatus DMV
6 Oct. 1987 Virginia T. truncatus DMV
7 Oct. 1987 Virginia T. truncatus DMV
21 Dec. 1987 Florida (Atlantic Coast) T. truncatus PMV
21 Dec. 1987 Florida (Atlantic Coast) T. truncatus PMV
1 Jan. 1988 Florida (Atlantic Coast) T. truncatus PMV
18 Jan. 1988 Florida (Atlantic Coast) T. truncatus PMV
9 Feb. 1988 Florida (Atlantic Coast) T. truncatus DMV
9 Feb. 1988 Florida (Atlantic Coast) T. truncatus PMV
10 Feb. 1988 Florida (Atlantic Coast) T. truncatus DMV
4 Apr. 1993 Texas T. truncatus PMV
4 Apr. 1993 Texas T. truncatus PMV
4 Apr. 1993 Texas T. truncatus PMV
11 Apr. 1993 Texas T. truncatus PMV
15 Apr. 1993 Texas T. truncatus PMV
19 Apr. 1993 Texas T. truncatus PMV
21 Apr. 1993 Texas T. truncatus PMV
1991 Mediterranean Sea S. coeruloalba DMV
1991 Mediterranean Sea S. coeruloalba DMV
1991 Mediterranean Sea S. coeruloalba DMV
1991 Mediterranean Sea S. coeruloalba DMV
1988 Northern Ireland Phocoena phocoena PMV

a RNA isolation, RT-PCR, and cycle sequencing were performed (11,20).

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References
  1. Diallo  A. Morbillivirus group: genome organization and proteins. Vet Microbiol. 1990;23:15563.
  2. Haas  L, Subbarao  SM, Harder  T, Liess  B, Barrett  T. Detection of phocid distemper virus RNA in seal tissues using slot hybridization and the polymerase chain reaction amplification assay: genetic evidence that the virus is distinct from canine distemper virus. J Gen Virol. 1991;72:825–32. DOIPubMedGoogle Scholar
  3. Osterhaus  ADME, Groen  J, Spijkers  HEM, Broeders  HWJ, UytdeHaag  FGCM, de Vries  P, . Mass mortality in seals caused by a newly discovered virus-like morbillivirus. Vet Microbiol. 1990;23:343–50. DOIPubMedGoogle Scholar
  4. McCullough  SJ, McNeilly  F, Allan  GM, Kennedy  S, Smyth  JA, Cosby  SL, . Isolation and characterization of a porpoise morbillivirus. Arch Virol. 1991;118:247–52. DOIPubMedGoogle Scholar
  5. Osterhaus  ADME, Visser  IKG, de Swart  RL, van Bressem  MF, van de Bildt  MWG, Örvell  C, Morbillivirus threat to Mediterranean monk seals? Vet Rec. 1992;130:141–2.PubMedGoogle Scholar
  6. Domingo  M, Ferrer  L, Pumarola  M, Marco  A, Plana  J, Kennedy  S, . Morbillivirus in dolphins. Nature. 1990;348:21.PubMedGoogle Scholar
  7. Van Bressem  MF, Visser  IKG, de Swart  RL, Örvell  C, Stanzani  L, Androukaki  E, . Dolphin morbillivirus infection in different parts of the Mediterranean Sea. Arch Virol. 1993;129:235–42. DOIPubMedGoogle Scholar
  8. Lipscomb  TP, Schulman  FY, Moffett  D, Kennedy  S. Morbilliviral disease in Atlantic bottlenose dolphins (Tursiops truncatus) from the 1987-88 epizootic. J Wildl Dis. 1994;30:567–71.PubMedGoogle Scholar
  9. Schulman  FY, Lipscomb  TP, Moffett  D, Krafft  AE, Lichy  JH, sai MM, et al. Reevaluation of the 1987-88 Atlantic coast bottlenose dolphin (Tursiops truncatus) mortality event with histologic, immunohistochemical, and molecular evidence for a morbilliviral etiology. In preparation, 1996.
  10. Lipscomb  TP, Kennedy  S, Moffett  D, Ford  BK. Morbilliviral disease in an Atlantic bottlenose dolphin (Tursiops truncatus) from the Gulf of Mexico. J Wildl Dis. 1994;30:572–6.PubMedGoogle Scholar
  11. Krafft  AE, Lichy  JH, Lipscomb  TP, Klaunberg  BA, Kennedy  S, Taubenberger  JK. Postmortem diagnosis of morbillivirus infection in bottlenose dolphins (Tursiops truncatus) in the Atlantic and Gulf of Mexico Epizootics by a polymerase chain reaction-based assay. J Wildl Dis. 1995;31:410–5.PubMedGoogle Scholar
  12. Barrett  T, Visser  IKG, Mamaev  L, Goatley  L, van Bressem  MF, Osterhaus  ADME. Dolphin and porpoise morbilliviruses are genetically distinct from phocine distemper virus. Virology. 1993;193:1010–2. DOIPubMedGoogle Scholar
  13. Lipscomb  TP, Kennedy  S, Moffett  D, Krafft  AE, Klaunberg  BA, Lichy  JH, Morbilliviral epizootic in Atlantic bottlenose dolphins of the Gulf of Mexico. J Vet Diagn Invest. 1996. In press.PubMedGoogle Scholar
  14. Visser  IKG, van Bressem  MF, de Swart  RL, van de Bildt  MWG, Vos  HW, van der Heijden , RWJ, . Characterization of morbilliviruses isolated from dolphins and porpoises in Europe. J Gen Virol. 1993;74:631–41. DOIPubMedGoogle Scholar
  15. Kenney  RD. Bottlenose dolphins off the northeastern United States. In: Leatherwood S, Reeves RR, editors. The bottlenose dolphin. San Diego: Academic Press, 1990:369-86.
  16. Breslow  NE, Day  NE. Statistical methods in cancer research.Vol. 1 Lyon, France. International Agency for Research on Cancer, 1980.
  17. Geraci  JR. Clinical investigation of the 1987-88 mass mortality of bottlenose dolphins along the US central and south Atlantic coast: final report to National Marine Fisheries Service and U.S. Navy. Guelph, Canada: Office of Naval Research, and Marine Mammal Commission; 1989.
  18. Duignan  PJ, House  C, Geraci  JR, Duffy  N, Rima  BK, Walsh  MT, Morbillivirus infections in cetaceans of the western Atlantic. Vet Microbiol. 1995;44:241–9. DOIPubMedGoogle Scholar
  19. Duignan  PJ, House  C, Geraci  JR, Early  G, Copland  H, Walsh  MT, Morbillivirus infection in two species of pilot whales (Globicephala sp.) from the western Atlantic. Mar Mamm Sci. 1995;11:150–62. DOIGoogle Scholar
  20. Reid  AH, Tsai  MM, Venzon  DJ, Wright  CF, Lack  EE, O'Leary  TJ. MDM2 amplification, P53 mutation, and accumulation of the P53 gene product in malignant fibrous histiocytoma. Diagn Mol Pathol. 1996;5:65–73. DOIPubMedGoogle Scholar
  21. Kovalic  D, Kwak  JH, Weisblum  B. General method for direct cloning of DNA fragments generated by the polymerase chain reaction. Nucleic Acids Res. 1991;19:4560. DOIPubMedGoogle Scholar

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