Volume 10, Number 4—April 2004
Research
Antigenic and Genetic Variability of Human Metapneumoviruses
Bernadette G. van den Hoogen*, Sander Herfst*, Leo Sprong*, Patricia A. Cane†, Eduardo Forleo-Neto‡, Rik L. de Swart*, Albert D.M.E. Osterhaus*, and Ron A.M. Fouchier*
Table 3
Homologous and heterologous virus neutralizing antibody titers of sera obtained from ferrets infected with HMPV viruses belonging to different genetic sublineagesa,b
| Virus used in virus neutralization | Ferret 3 NL/1/00 [A1] | Ferret 4 NL/17/00 [A2] | Ferret 5 NL/1/99 [B1] | Ferret 6 UK/5/01 [B2] |
|---|---|---|---|---|
| NL/ 1/00 |
256 |
256 |
6 |
32 |
| NL/17/00 |
512 |
768 |
12 |
24 |
| NL/ 1/99 |
16 |
32 |
256 |
384 |
| UK/ 5/01 |
12 |
64 |
256 |
512 |
| Ratio A–B Ratio B–A | 16–21 | 12–24 | 21–43 | 16–21 |
aVirus neutralizing antibody titers obtained for sera collected 21 days post infection from ferrets 3 to 6 (infected with NL/1/00, NL/17/00, NL/1/99 and UK/5/01, respectively). HMPV, human metapneumovirus.
bHomologous virus neutralization titers are bold. Values are average of duplicate measurements. Ratios are given as the homologous virus neutralization titers divided by the heterologous virus neutralization titers.
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