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Volume 10, Number 4—April 2004
Research
Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France
Anne Totet*, Sophie Latouche†, Philippe Lacube†, Jean-Claude Pautard*, Vincent Jounieaux*, Christian Raccurt*, Patricia Roux†, and Gilles Nevez*
Table 2
Pneumocystis jiroveci dihydropteroate synthase (DHPS) genotypes in immunocompetent infants with mild infection and in immunosuppressed adults with Pneumocystis pneumonia, University Hospital of Amiens, France
| DHPS genotype | Nucleotide at position (amino acid at position) |
Infants | Adults | ||
|---|---|---|---|---|---|
| 165 (55) | 171 (57) | ||||
| Wild genotypea |
A (Thr) |
C (Pro) |
30 |
12 |
|
| A (Thr) |
T (Ser) |
–b |
– |
||
| Double mutant genotypea |
G (Ala) |
T (Ser) |
– |
– |
|
| Wild genotype + mutant genotypec |
A/G (Thr/Ala) |
C (Pro) |
1 |
– |
|
| Wild genotype + mutant genotyped |
A (Thr) |
C/T (Pro/Ser) |
2 |
1 |
|
| Wild genotype + double mutant genotypee |
A/G (Thr/Ala) |
C/T (Pro/Ser) |
– |
– |
|
| Undetermined genotype | – | – | 12f | – | |
aInfection with a single genotype.
b–, absence.
c, d, e Mixed infections related to the association of a wild genotype with a mutant genotype.
cMutant genotype with a mutation at nucleotide position 165 (amino acid position 55).
dMutant genotype with a mutation at nucleotide position 171 (amino acid position 57).
eDouble mutant with both mutations at nucleotide positions 165 and 171.
fAbsence of DHPS amplification despite initial detection by polymerase chain reaction at mtLSUrRNA.
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