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Volume 10, Number 5—May 2004

Endemic Venezuelan Equine Encephalitis in Northern Peru

Patricia V. Aguilar*, Ivorlyne P. Greene*, Lark L. Coffey*, Gladys Medina*1, Abelardo C. Moncayo*2, Michael Anishchenko*, George V. Ludwig†, Michael J. Turell‡, Monica L. O’Guinn‡, John Lee‡, Robert B. Tesh*, Douglas M. Watts†, Kevin L. Russell†, Christine Hice*, Stephen Yanoviak*, Amy C. Morrison§, Terry A. Klein‡, David J. Dohm‡, Hilda Guzman*, Amelia P.A. Travassos da Rosa*, Carolina Guevara†, Tadeusz J. Kochel†, James Olson†, Cesar Cabezas¶, and Nikos Vasilakis*Comments to Author 
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Naval Medical Research Center Detachment, Lima, Peru; ‡U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA; §University of California, Davis, California, USA; ¶Instituto Nacional de Salud, Lima, Peru

Main Article

Figure 4

Unrooted phylogenetic tree of the Venezuelan equine encephalitis virus (VEEV) complex and other representative alphaviruses derived from complete structural polyprotein sequences using the neighbor joining program implemented in PAUP 4.0 (22). Viruses are labeled by species according to the International Committee for Taxonomy of Viruses (27). VEEV subtype IIIC and IIID strain names are in parentheses. Numbers indicate bootstrap values for clades to the right.

Figure 4. Unrooted phylogenetic tree of the Venezuelan equine encephalitis virus (VEEV) complex and other representative alphaviruses derived from complete structural polyprotein sequences using the neighbor joining program implemented in PAUP 4.0 (22). Viruses are labeled by species according to the International Committee for Taxonomy of Viruses (27). VEEV subtype IIIC and IIID strain names are in parentheses. Numbers indicate bootstrap values for clades to the right.

Main Article

  1. Kubes  V, Rios  FA. The causative agent of infectious equine encephalomyelitis in Venezuela. Science. 1939;90:201. DOIPubMed
  2. Oberste  MS, Fraire  M, Navarro  R, Zepeda  C, Zarate  ML, Ludwig  GV, Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico. Am J Trop Med Hyg. 1998;59:1007.PubMed
  3. Lord  RD. History and geographic distribution of Venezuelan equine encephalitis. Bull Pan Am Health Organ. 1974;8:10010.PubMed
  4. Watts  DM, Callahan  J, Rossi  C, Oberste  MS, Roehrig  JT, Wooster  MT, Venezuelan equine encephalitis febrile cases among humans in the Peruvian Amazon River region. Am J Trop Med Hyg. 1998;58:3540.PubMed
  5. Weaver  SC, Salas  R, Rico-Hesse  R, Ludwig  GV, Oberste  MS, Boshell  J, Re-emergence of epidemic Venezuelan equine encephalomyelitis in South America. VEE Study Group. Lancet. 1996;348:43640. DOIPubMed
  6. Weaver  SC. Recurrent emergence of Venezuelan equine encephalomyelitis. In: Scheld WM and J Hughes. Emerging infections I. Washington: ASM Press; 1998. p. 27–42.
  7. Johnson  KM, Martin  DH. Venezuelan equine encephalitis. Adv Vet Sci Comp Med. 1974;18:79116.PubMed
  8. Walton  TE, Grayson  MA. Venezuelan equine encephalomyelitis. In: Monath TP. The arboviruses: epidemiology and ecology, vol. IV. Boca Raton (FL): CRC Press; 1988. p. 203–31.
  9. Oberste  MS, Weaver  SC, Watts  DM, Smith  JF. Identification and genetic analysis of Panama-genotype Venezuelan equine encephalitis virus subtype ID in Peru. Am J Trop Med Hyg. 1998;58:416.PubMed
  10. Johnson  KM, Shelokov  A, Peralta  PH, Dammin  GJ, Young  NA. Recovery of Venezuelan equine encephalomyelitis virus in Panama. A fatal case in man. Am J Trop Med Hyg. 1968;17:43240.PubMed
  11. Scherer  WF, Madalengoitia  J, Flores  W, Acosta  M. The first isolations of eastern encephalitis, group C, and Guama group arboviruses from the Peruvian Amazon region of western South America. Bull Pan Am Health Organ. 1975;9:1926.PubMed
  12. Scherer  WF, Anderson  K. Antigenic and biologic characteristics of Venezuelan encephalitis virus strains including a possible new subtype isolated from the Amazon region of Peru in 1971. Am J Epidemiol. 1975;101:35661.PubMed
  13. Scherer  WF, Chin  J. An unusual strain of Venezuelan encephalitis virus existing sympatrically with subtype I-D strains in a Peruvian rain forest. Am J Trop Med Hyg. 1983;32:8716.PubMed
  14. Watts  DM, Lavera  V, Callahan  J, Rossi  C, Oberste  MS, Roehrig  JT, Venezuelan equine encephalitis and Oropouche virus infections among Peruvian army troops in the Amazon region of Peru. Am J Trop Med Hyg. 1997;56:6617.PubMed
  15. Powers  AM, Oberste  MS, Brault  AC, Rico-Hesse  R, Schmura  SM, Smith  JF, Repeated emergence of epidemic/epizootic Venezuelan equine encephalitis from a single genotype of enzootic subtype ID virus. J Virol. 1997;71:6697705.PubMed
  16. Wang  E, Barrera  R, Boshell  J, Ferro  C, Freier  JE, Navarro  JC, Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor. J Virol. 1999;73:426671.PubMed
  17. Weaver  SC, Bellew  LA, Rico-Hesse  R. Phylogenetic analysis of alphaviruses in the Venezuelan equine encephalitis complex and identification of the source of epizootic viruses. Virology. 1992;191:28290. DOIPubMed
  18. Weaver  SC, Pfeffer  M, Marriott  K, Kang  W, Kinney  RM. Genetic evidence for the origins of Venezuelan equine encephalitis virus subtype IAB outbreaks. Am J Trop Med Hyg. 1999;60:4418.PubMed
  19. Moncayo  AC, Medina  GM, Kalvatchev  Z, Brault  AC, Barrera  R, Boshell  J, Genetic diversity and relationships among Venezuelan equine encephalitis virus field isolates from Colombia and Venezuela. Am J Trop Med Hyg. 2001;65:73846.PubMed
  20. Pfeffer  M, Proebster  B, Kinney  RM, Kaaden  OR. Genus-specific detection of alphaviruses by a semi-nested reverse transcription-polymerase chain reaction. Am J Trop Med Hyg. 1997;57:70918.PubMed
  21. Black  WC, Vanlandingham  DL, Sweeney  WP, Wasieloski  LP, Calisher  CH, Beaty  BJ. Typing of LaCrosse, snowshoe hare, and Tahyna viruses by analyses of single-strand conformation polymorphisms of the small RNA segments. J Clin Microbiol. 1995;33:317982.PubMed
  22. Swofford  DL. PAUP*. Phylogenetic analysis using parsimony (*and Other Methods). Version 4. Sunderland (MA): Sinauer Associates; 1998. p.
  23. Felsenstein  J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution. 1985;39:78391. DOI
  24. Beaty  BJ, Calisher  CH, Shope  RE. Arboviruses. In: Schmidt NJ, RW Emmons, editors. Diagnostic procedures for viral, rickettsial and chlamydial infections. 6th ed. Washington: American Public Health Association; 1989. p. 797–855.
  25. Rico-Hesse  R, Weaver  SC, de Siger  J, Medina  G, Salas  RA. Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America. Proc Natl Acad Sci U S A. 1995;92:527881. DOIPubMed
  26. Brault  AC, Powers  AM, Chavez  CL, Lopez  RN, Cachon  MF, Gutierrez  LF, Genetic and antigenic diversity among eastern equine encephalitis viruses from North, Central, and South America. Am J Trop Med Hyg. 1999;61:57986.PubMed
  27. Weaver  SC, Dalgarno  L, Frey  TK, Huang  HV, Kinney  RM, Rice  CM, Family Togaviridae. In: van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, et al. Virus taxonomy. Classification and nomenclature of viruses. Seventh report of the International Committee on Taxonomy of Viruses. San Diego: Academic Press; 2000. p. 879–89.
  28. Calisher  CH, Shope  RE, Brandt  W, Casals  J, Karabatsos  N, Murphy  FA, Proposed antigenic classification of registered arboviruses I. Togaviridae, Alphavirus. Intervirology. 1980;14:22932. DOIPubMed
  29. Turell  MJ, Jones  JW, Sardelis  MR, Dohm  DJ, Coleman  RE, Watts  DM, Vector competence of Peruvian mosquitoes (Diptera: Culicidae) for epizootic and enzootic strains of Venezuelan equine encephalomyelitis virus. J Med Entomol. 2000;37:8359. DOIPubMed
  30. Ferro  C, Boshell  J, Moncayo  AC, Gonzalez  M, Ahumada  ML, Kang  W, Natural enzootic vectors of Venezuelan equine encephalitis virus, Magdalena Valley, Colombia. Emerg Infect Dis. 2003;9:4954.PubMed
  31. Salas  RA, Garcia  CZ, Liria  J, Barrera  R, Navarro  JC, Medina  G, Ecological studies of enzootic Venezuelan equine encephalitis in north-central Venezuela, 1997–1998. Am J Trop Med Hyg. 2001;64:8492.PubMed
  32. Briceno Rossi  AL. Rural epidemic encephalitis in Venezuela caused by a group A arbovirus (VEE). Prog Med Virol. 1967;9:176203.PubMed
  33. Young  NA, Johnson  KM. Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance. Am J Epidemiol. 1969;89:286307.PubMed
  34. Vasconcelos  PF, Travassos da Rosa  JF, Travassos da Rosa  AP, Degallier  N, Pinheiro  FP, Sa Filho  GC. [Epidemiology of encephalitis caused by arbovirus in the Brazilian Amazonia]. Rev Inst Med Trop Sao Paulo. 1991;33:46576. DOIPubMed
  35. Rivas  F, Diaz  LA, Cardenas  VM, Daza  E, Bruzon  L, Alcala  A, Epidemic Venezuelan equine encephalitis in La Guajira, Colombia, 1995. J Infect Dis. 1997;175:82832. DOIPubMed

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1Current affiliation is Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

2Current affiliation is Department of Biological Sciences, Ohio Northern University, Ada, Ohio.

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