Volume 11, Number 8—August 2005
Research
Cephalosporin-resistant Pneumococci and Sickle Cell Disease
Table 1
Distribution of β-lactam resistance in nasopharyngeal pneumococcal isolates from sickle cell disease patients
Penicillin susceptibility* | No. isolates | Cefotaxime susceptibility* | No. isolates |
---|---|---|---|
Sensitive | 31 | Sensitive | 31 |
Intermediate | 24 | Sensitive | 19 |
Intermediate | 3 | ||
Resistant | 2 | ||
Resistant | 9 | Intermediate | 3 |
Resistant | 6 |
*Definition of susceptibility per Clinical and Laboratory Standards Institute (formerly NCCLS) guidelines from 1994 and 1995 (10,11). Sensitive, penicillin V MIC<0.06 μg/mL, cefotaxime MIC<0.05 μg/mL; intermediate, penicillin V MIC 0.12–1 μg/mL, cefotaxime MIC 1 μg/mL; resistant, penicillin or cefotaxime MIC>2 μg/mL.
1These authors contributed equally to this study.