Volume 12, Number 1—January 2006
Vaccines for Pandemic Influenza
|What we know from experience with human influenza viruses||What we don’t know|
|Antibodies against the HA (and to a lesser extent NA) are critical for protection. Systemic immune response is strain specific. Mucosal immune response provides broader cross-protection. Cellular immunity is needed for viral clearance. Vaccine strain must closely match the circulating strain.||Which avian influenza virus will cross species barrier to cause a pandemic Importance of antigenic drift among avian influenza viruses Immunogenicity of HA of avian viruses in humans (unknown or poor)|
*HA, hemagglutinin; NA, neuraminidase.
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