Volume 12, Number 1—January 2006
Vaccines for Pandemic Influenza
|In vitro testing||In vivo testing|
|Confirmation of virus genome sequence Trypsin-dependent replication in cell culture Confirmation of phenotype associated with the vaccine donor virus, e.g., temperature sensitivity, cold adaptation||Intravenous pathogenicity test in chickens Attenuation (restricted replication) in rodent or ferret model Immunogenicity in rodent or ferret model Protective efficacy in rodent model|
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