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Volume 12, Number 1—January 2006


Vaccines for Pandemic Influenza

Catherine J. Luke* and Kanta Subbarao*Comments to Author 
Author affiliations: *National Institutes of Health, Bethesda, Maryland, USA

Main Article

Table 4

Preclinical testing to be performed on live attenuated pandemic influenza vaccine candidates

In vitro testing In vivo testing
Confirmation of virus genome sequence
Trypsin-dependent replication in cell culture
Confirmation of phenotype associated with the vaccine donor virus, e.g., temperature sensitivity, cold adaptation Intravenous pathogenicity test in chickens
Attenuation (restricted replication) in rodent or ferret model
Immunogenicity in rodent or ferret model
Protective efficacy in rodent model

Main Article