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Volume 12, Number 10—October 2006
Research

Health Benefits, Risks, and Cost-Effectiveness of Influenza Vaccination of Children

Lisa A. Prosser*†Comments to Author , Carolyn Buxton Bridges‡, Timothy M. Uyeki‡, Virginia L. Hinrichsen*†, Martin I. Meltzer‡, Noelle-Angelique M. Molinari‡, Benjamin Schwartz‡, William W. Thompson‡, Keiji Fukuda‡, and Tracy A. Lieu*†§
Author affiliations: *Harvard Medical School, Boston, Massachusetts, USA; †Harvard Pilgrim Health Care, Boston, Massachusetts, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA; §Children's Hospital, Boston, Massachusetts, USA

Main Article

Table 3

Quality adjustments for influenza-related illness and vaccination-related adverse events (decrease in utility)*†

Events Most likely estimate Range for sensitivity analysis
Episode of influenza 0.005 0.002-0.009
Otitis media 0.042 0.023-0.065
Nonhospitalized complications (pneumonia) 0.046 0.027-0.071
Hospitalization, pneumonia 0.076 0.054-0.100
Anaphylaxis 0.020 0.006-0.041
Guillain-Barré syndrome 0.141 0.092-0.199

*Quality adjustments are included in model as a one-time decrement in utility for each temporary health state. For example, an episode of influenza results in a 1-time loss of 0.005 quality-adjusted life years (QALYs). Utility losses were calculated by dividing discounted time-traded off by respondent's discounted life expectancy. See appendix for references.
†Average life span used to calculate total QALYs lost due to lifelong sequelae and death was 77.9–78.2 years, depending on child's current age.

*Quality adjustments are included in model as a one-time decrement in utility for each temporary health state. For example, an episode of influenza results in a 1-time loss of 0.005 quality-adjusted life years (QALYs). Utility losses were calculated by dividing discounted time-traded off by respondent's discounted life expectancy. See appendix for references.
†Average life span used to calculate total QALYs lost due to lifelong sequelae and death was 77.9–78.2 years, depending on child's current age.

Main Article

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Page updated: November 09, 2011
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