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Volume 12, Number 4—April 2006

Identifying Influenza Viruses with Resequencing Microarrays

Zheng Wang*†, Luke T. Daum‡, Gary J. Vora*, David Metzgar§, Elizabeth A. Walter¶, Linda C. Canas‡, Anthony P. Malanoski*, Baochuan Lin*, and David A. Stenger*Comments to Author 
Author affiliations: *Naval Research Laboratory, Washington, DC, USA; †NOVA Research Inc., Alexandria, Virginia, USA; ‡Air Force Institute for Operational Health, Brooks City Base, San Antonio, Texas, USA; §Naval Health Research Center, San Diego, California, USA; ¶Lackland Air Force Base, San Antonio, Texas, USA

Main Article

Table 3

Nucleotide differences among hemagglutinin (HA) influenza virus genes identified by respiratory pathogen microarray (RPM) version 1

Position† TN‡ Mismatched nucleotides*
1 2 3 4 5 6 7 8 9 10 11 12
25 T C
46 T A
61 A T
62§ G A
88 G T
189 G A
208 T C
233§ G A
244 G A
251§ G A A
262 C T
274 G A
293§ A G
299 G A A A A A A A A A A A A
313§ G A A A A A A A A A A A
351§ A G G G
352 A C C C C C C C C C C
385 C T
393§ A T T T T T T T T T T T
407 T C
429§ A G
434§ A G G
446§ T C
466 C T
469 C T
473§ G A
478 T A A
479§ G T T
483§ G A A A A A A A A A A A
493 C T
511 A T T
559 C T
564§ A G
584§ G A
571 A G G
593§ G A A A A A A A A A
596§ T C C C C C C C C C C C
602§ A C
646 T C
652 T A
698§ C A
734§ C T

*Mismatched nucleotides obtained from comparison between the tiled probe sequence and the conventional sequence. Mismatched nucleotides identified by the RPM version 1 are shown in boldface. 1–12 represent 12 influenza A/H3N2 isolates. 1, A/Colorado/360/05; 2, A/Ecuador/1968/04; 3, A/Guam/362/05; 4, A/Iraq/34/05; 5, A/Italy/384/05; 6, A/Japan/1337/05; 7, A/Japan/1383/05; 8, A/Korea/298/05; 9, A/New York/278/04; 10, A/Peru/166/05; 11, A/Qatar/2039/05; 12, A/Turkey/2108/05.
†HA3 tiled prototype sequence nucleotide position.
‡Tiled nucleotide.
§Potential nonsynonymous mutation position.

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Page created: January 24, 2012
Page updated: January 24, 2012
Page reviewed: January 24, 2012
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