Volume 12, Number 7—July 2006
Letter
Panton-Valentine Leukocidin Genes in Staphylococcus aureus
Damian C. Melles*
, Willem B. van Leeuwen*, Hélène A.M. Boelens*, Justine K. Peeters*, Henri A. Verbrugh*, and Alex van Belkum*
, Willem B. van Leeuwen*, Hélène A.M. Boelens*, Justine K. Peeters*, Henri A. Verbrugh*, and Alex van Belkum*
Table
Panton-Valentine Leukocidin (PVL) distribution among carriage and invasive isolates per genetic cluster of Staphylococcus aureus
| Amplified fragment length polymorphism cluster |
||||||
|---|---|---|---|---|---|---|
| I
(n = 462) |
II
(n= 261) |
III
(n = 208) |
IVa
(n = 62) |
IVb
(n = 40) |
Total
(N = 1,033) |
|
| PVL positive, n (%) | ||||||
| Carriage isolates (n = 829) | 1 | 1 | 1 | 0 | 2 | 5 (0.6)* |
| Bacteremia isolates (n = 146) | 1 | 1 | 0 | 0 | 1 | 3 (2.1)† |
| Soft tissue infection isolates (n = 18) | 1 | 5 | 0 | 1 | 0 | 7 (38.9)‡ |
| Impetigo isolates (n = 40) | 0 | 0 | 0 | 0 | 0 | 0 (0.0) |
| Total (N = 1,033) | 3 (0.6)§ | 7 (2.7) | 1 (0.5)¶ | 1 (1.6) | 3 (7.5)# | 15 (1.5) |
| MLST** data of PVL-positive isolates | CC 1, n = 2 CC 8, n = 1 | CC 30, n = 7 | CC 45, n = 1 | CC 22, n = 1 | CC 121, n = 3 | |
‡versus *Fisher exact test (2-sided); p<0.0001.
‡versus †Fisher exact test (2-sided); p<0.0001.
#versus §Fisher exact test (2-sided); p = 0.0079.
#versus ¶Fisher exact test (2-sided); p = 0.0140.
**MLST, multilocus sequence typing; CC, clonal complex.
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