Volume 13, Number 12—December 2007
Research
Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model
Thierry G.M. Baron*
, Anna Bencsik*, Anne-Gaëlle Biacabe*, Eric Morignat*, and Richard A. Bessen†
, Anna Bencsik*, Anne-Gaëlle Biacabe*, Eric Morignat*, and Richard A. Bessen†
Table
TSE sources transmitted to TgOvPrP4 mice*
| TSE sources | Nature | First passage |
Second passage |
|||
|---|---|---|---|---|---|---|
| Survival periods (mean ± SD dpi) | No. PrPd positive mice/total† | Survival periods (mean ± SD dpi) | No. PrPd positive mice/total† | |||
| Experimental isolates | ||||||
| TME | TME | 436 ± 77 | 9/11 | 234 ± 27 | 9/9 | |
| SB1 |
Ovine BSE |
296 ± 46 |
19/19 |
365 ± 36 |
11/12 |
|
| Natural isolates | ||||||
| 02-2528 | L-type BSE | 627 ± 74 | 9/10 | 202 ± 26 | 9/9 | |
| 03-2095 | H-type BSE | 692 ± 129 | 0/8 | ND | ND | |
| 01-2281 | Typical BSE | 421 ± 48 | 10/10 | 354 ± 48 | 10/10 | |
*TSE, transmissible spongiform encephalopathy; dpi, days postinoculation; PrPd, disease-associated prion protein; TME, transmissible mink encephalopathy; BSE, bovine spongiform encephalopathy; ND, not done.
†Results obtained by Western blot or by immunohistochemical test.
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