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Volume 13, Number 6—June 2007


Levels of Abnormal Prion Protein in Deer and Elk with Chronic Wasting Disease

Brent L. Race*, Kimberly D. Meade-White*, Anne Ward*, Jean Jewell†, Michael W. Miller‡, Elizabeth S. Williams†1, Bruce Chesebro*, and Richard E. Race*Comments to Author 

Author affiliations: *Rocky Mountain Laboratories, Hamilton, Montana, USA; †University of Wyoming, Laramie, Wyoming, USA; ‡Colorado Division of Wildlife, Fort Collins, Colorado, USA;

Main Article

Table 1

PrPres detection by immunoblot in brain and lymphoid tissues of elk and deer*

Species Brain Spleen Tonsil Lymph node
Elk 10/10 2/10 4/9 5/10
Mule deer 12/12 2/10 9/10 12/12
White-tailed deer 3/3 1/3 2/3 3/3

*PrPres, disease-associated prion protein. Values indicate the number of animals with PrPres detected (numerator) over the number analyzed (denominator). If any PrPres was detected in a given tissue, it was considered positive for the purpose of this table. If even a single lymph node from a given animal was positive, the animal was scored as positive for that tissue. This table does not consider quantitative variation in the amount of PrPres in tissues of elk compared to deer. The denominators vary because not every tissue was available from every animal. Brain, tonsil, and lymph nodes of elk did not differ significantly from mule deer (Fisher exact test).

Main Article