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Volume 13, Number 7—July 2007


Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections

Victor L. Yu*Comments to Author , Dennis S. Hansen†, Wen Chien Ko‡, Asia Sagnimeni*, Keith P. Klugman§, Herman Goossens#, Marilyn M. Wagener*, Vicente J. Benedi**1, Meningeal Disease Surveillance in South Africa¶, and the International Klebsiella Study Group

Author affiliations: *University of Pittsburgh, Pittsburgh, Pennsylvania, USA; †Statens Serum Institut, Copenhagen, Denmark; ‡National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China; §Emory University, Atlanta, Georgia, USA; ¶South African Institute of Medical Research, Johannesburg, South Africa; #University Hospital, Antwerp, Belgium; **Universidad de las Islas Baleares, Palma de Mallorca, Spain;

Main Article

Table 2

Strain source and virulence factors, Taiwan and South Africa*

Infection type K1 or K2 
serotype, % Mucoid 
phenotype, % Aerobactin 
producer, % Mouse 
mortality rate, %†
Community-acquired pneumonia 49 (23/47) 68 (32/47) 66 (31/47) 47
Invasive syndrome 54 (7/13) 100 (13/13) 85 (11/13) 82
Other community-acquired 15 (8/55) 38 (21/55) 42 (23/55) 36
Hospital-acquired 16 (6/38) 18 (7/37) 16 (6/38) 7

*Note that strains from patients in Taiwan and South Africa with community-acquired pneumonia or the invasive syndrome (liver abscess, endophthalmitis, meningitis) were more likely to have the putative virulence factors than hospital-acquired strains. See Results for p values.
†2 mice were tested for each available strain.

Main Article


2The International Klebsiella Study Group comprises the previously named authors plus Jose Maria Casellas, Gordon Trenholme, Joseph McCormack, Sunita Mohapatra, and Lutfiye Mulazimoglu.