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Volume 13, Number 7—July 2007


Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections

Victor L. Yu*Comments to Author , Dennis S. Hansen†, Wen Chien Ko‡, Asia Sagnimeni*, Keith P. Klugman§, Herman Goossens#, Marilyn M. Wagener*, Vicente J. Benedi**1, Meningeal Disease Surveillance in South Africa¶, and the International Klebsiella Study Group

Author affiliations: *University of Pittsburgh, Pittsburgh, Pennsylvania, USA; †Statens Serum Institut, Copenhagen, Denmark; ‡National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China; §Emory University, Atlanta, Georgia, USA; ¶South African Institute of Medical Research, Johannesburg, South Africa; #University Hospital, Antwerp, Belgium; **Universidad de las Islas Baleares, Palma de Mallorca, Spain;

Main Article

Table 3

Underlying disease and virulence factors in community-acquired K. pneumoniae pneumonia*

Country/condition K1 or K2 
serotype, % Mucoid 
phenotype, % Aerobactin production, % Mouse 
mortality rate, %†
South Africa 50 (12/24) 75 (18/24) 67 (16/24) 58
No underlying disease 63 (12/19) 89 (17/19) 79 (15/19) 78
Underlying disease‡ 0 (0/5) 20 (1/5) 20 (1/5) 0
Taiwan 48 (11/43) 65 (15/23) 57 (13/23) 35
No underlying disease 75 (9/12) 100 (12/12) 83 (10/12) 50
Underlying disease‡ 18 (2/11) 18 (2/11) 27 (3/11) 18

*Note that patients with no underlying disease were more likely to be infected by strains with the putative risk factors than were elderly patients or patients with serious underlying disease. See Results for p values.
†2 mice were tested for each available strain.
‡Underlying disease was defined as presence of end-stage liver or renal failure, metastatic malignancy, neutropenia, or age >70.

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2The International Klebsiella Study Group comprises the previously named authors plus Jose Maria Casellas, Gordon Trenholme, Joseph McCormack, Sunita Mohapatra, and Lutfiye Mulazimoglu.