Volume 13, Number 8—August 2007
Research
Source of Variant Creutzfeldt-Jakob Disease outside United Kingdom
Pascual Sanchez-Juan*†, Simon N. Cousens‡, Robert G. Will§, and Cornelia M. van Duijn*
Table 2
Results of nonparametric correlation analyses between number of variant Creutzfeldt-Jakob disease (vCJD) cases and the 3 studied exposure sources*
| Countries and vCJD case-patients included in analysis | Exposure |
||
|---|---|---|---|
| Indigenous BSE cases (CI, p value) | Live bovines imported from UK, 1980–1990 (CI, p value)† | Carcass meat imported from UK, 1980–1996 (CI, p value)† | |
| All EU network countries | |||
| Patients likely to have been infected in UK excluded | rs = 0.70 (CI 0.37–0.87, p = 0.001) | rs = 0.73 (0.42–0.89, p<0.001) | rs = 0.75 (0.45–0.89, p<0.001) |
| Patients likely to have been
infected in UK included |
rs = 0.60
(0.21–0.82, p = 0.005) |
rs = 0.63
(0.26–0.84, p = 0.003) |
rs = 0.64
(0.27–0.84, p = 0.003) |
| All EU network countries plus Japan and Saudi Arabia | |||
| Patients likely to have been infected in UK excluded | rs = 0.55 (0.17–0.79, p = 0.008) | rs = 0.65 (0.31–0.84, p = 0.001) | rs = 0.73 (0.45–0.88, p<0.001) |
| Patients likely to have been
infected in UK included |
rs = 0.51
(0.11–0.77, p = 0.02) |
rs = 0.52
(0.13–0.77, p = 0.01) |
rs = 0.57
(0.19–0.80, p = 0.006) |
| All countries except France | |||
| Patients likely to have been infected in UK excluded | rs = 0.48 (0.06–0.75, p = 0.03) | rs = 0.60 (0.23–0.81, p = 0.005) | rs = 0.68 (0.36–0.86, p = 0.001) |
| Patients likely to have been infected in UK included | rs = 0.44 (0.01–0.73, p = 0.05) | rs = 0.44 (0.01–0.73, p = 0.05) | rs = 0.49 (0.08–0.76, p = 0.02) |
*BSE, bovine spongiform encephalopathy; UK, United Kingdom; EU, European Union; CI, confidence interval; rs Spearman rank correlation coefficient.
†Weighted by the temporal distribution of the export in relation to the size of the BSE epizootic in the UK.
Page created: June 30, 2010
Page updated: June 30, 2010
Page reviewed: June 30, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.